MAGP-2 Activators
MAGP-2 Activators are a specialized category of chemical compounds that play a pivotal role in the enhancement of the microfibril-associated glycoprotein-2 (MAGP-2) activity. These activators operate by targeting the biochemical pathways or cellular processes that are intimately linked with the functional role of MAGP-2. For instance, certain small molecule agonists might interact with integrin receptors, which subsequently influence the extracellular matrix (ECM) interactions where MAGP-2 is a critical modulating component. By binding to the integrin receptors, these activators could initiate a cascade of intracellular signaling events leading to the stabilization of microfibrils and enhancing the structural integrity of the ECM. This mechanism is critical since MAGP-2 is known to regulate the bioavailability of transforming growth factor-beta (TGF-β), a potent multifunctional cytokine, by maintaining the ECM's architectural framework. The activators might also have a role in the modulation of TGF-β activity, which in turn could have downstream effects on the functionality of MAGP-2 in tissue repair and remodeling processes.
Furthermore, another subset of MAGP-2 Activators may exert their effects by influencing the oxidative state within the cellular milieu. Compounds that can modulate the redox balance within cells could indirectly enhance the activity of MAGP-2 by ensuring the optimal conformation and stability of the ECM proteins to which MAGP-2 binds. This is particularly significant because the proper function of MAGP-2 is contingent upon the precise formation of ECM protein complexes, and any disruption in the redox state can lead to aberrant ECM organization. By fostering an environment conducive to the correct assembly of these complexes, MAGP-2 Activators can facilitate the role of MAGP-2 in cellular signaling, ECM organization, and modulation of growth factor activities. Taken together, the actions of these activators culminate in the fortified activity of MAGP-2, underpinning its essential contributions to cellular architecture and signaling without the necessity of altering its expression levels or direct activation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid influences cellular differentiation pathways. MAGP-2, being involved in extracellular matrix (ECM) organization, may have its activity in ECM remodeling enhanced due to the increased turnover and differentiation of cells regulated by Retinoic Acid. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
Ascorbic Acid is essential for the hydroxylation of proline residues in collagen synthesis. MAGP-2, associated with the microfibrils of elastic fibers in the ECM, could have its functional interaction with collagen enhanced due to the improved stability and cross-linking of collagen fibers. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $45.00 $120.00 $185.00 | 3 | |
Copper acts as a cofactor for lysyl oxidase, an enzyme responsible for the cross-linking of collagen and elastin in the ECM. Enhanced cross-linking can indirectly increase the structural integrity of microfibrils that MAGP-2 associates with, enhancing its functional activity. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $30.00 | ||
Manganese is a cofactor for several enzymes, including those involved in glycosaminoglycan synthesis. By supporting the synthesis of these ECM components, it can indirectly enhance the structural framework that MAGP-2 contributes to. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $96.00 $334.00 | 50 | |
Lysophosphatidic acid (LPA) signals through its receptors to promote fibroblast activation and collagen synthesis. By stimulating the production of ECM components, LPA can indirectly enhance MAGP-2's role in ECM stabilization. | ||||||
Fibronectin | sc-29011 sc-29011A | 1 mg 5 mg | $140.00 $494.00 | 94 | ||
Fibronectin binds to integrins and other ECM components, facilitating ECM assembly. Its presence can enhance MAGP-2's role in the ECM organization by providing a more complex scaffold for MAGP-2 to interact with. | ||||||
Hyaluronic acid | 9004-61-9 | sc-337865 | 10 mg | $204.00 | ||
Hyaluronic acid is a major component of the ECM and can affect tissue hydration and turgidity. Enhanced ECM hydration can affect the biomechanical properties of tissues where MAGP-2 is active. | ||||||
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $65.00 $262.00 | 1 | |
Calcium ions are essential for the structure and function of the ECM, and they can modulate the interaction between MAGP-2 and other ECM components, such as elastin, potentially enhancing MAGP-2's role in ECM resilience. | ||||||
Magnesium chloride | 7786-30-3 | sc-255260C sc-255260B sc-255260 sc-255260A | 10 g 25 g 100 g 500 g | $27.00 $34.00 $47.00 $123.00 | 2 | |
Magnesium ions are critical for many enzymatic reactions, including those involved in the ECM synthesis and remodeling. The presence of magnesium could enhance MAGP-2's role in these processes by ensuring optimal enzyme function. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc is a cofactor for numerous enzymes, including those involved in protein synthesis and ECM remodeling. Zinc's presence may enhance MAGP-2 activity by promoting the synthesis of ECM proteins that interact with MAGP-2. | ||||||