MAGI-1b Activators
MAGI-1b is an integral scaffolding protein belonging to the membrane-associated guanylate kinase (MAGUK) family. These proteins play a pivotal role in the formation and regulation of various cell signaling complexes at synaptic junctions and are involved in maintaining the integrity of tight junctions in epithelial cells. MAGI-1b, in particular, has been identified as a key player in synaptic signaling pathways, contributing to the molecular organization of synaptic structures and the modulation of synaptic plasticity. The expression of MAGI-1b is critical for numerous cellular functions, including cell adhesion, signal transduction, and the maintenance of cellular architecture. The regulation of its expression is a sophisticated process, influenced by a multitude of intracellular and extracellular factors that can signal the need to adjust the concentration and distribution of this protein within the cell.
Various chemical compounds have the potential to induce the expression of proteins like MAGI-1b through diverse mechanisms that involve a cascade of intracellular signaling events. Compounds such as retinoic acid and beta-estradiol can interact with their respective nuclear hormone receptors to initiate transcriptional changes in genes. Epigenetic modulators, like 5-Azacytidine and Trichostatin A, can alter the chromatin structure, making it more conducive to gene transcription. Forskolin and Dibutyryl-cAMP, by increasing cAMP levels, may activate protein kinase A and subsequent phosphorylation of transcription factors like CREB, potentially leading to an increase in gene transcription. Additionally, compounds such as vitamin D3 and its analogs can stimulate transcription by interacting with the vitamin D receptor. Natural substances, including Epigallocatechin Gallate, Sulforaphane, and Curcumin, have also been shown to possess properties that could modulate gene expression through their influence on the cellular redox state and histone modification patterns. These compounds, among others, illustrate the diverse molecular pathways through which the expression of proteins, such as MAGI-1b, can be modulated without direct implications for medical applications.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid binds to and activates retinoic acid receptors that can stimulate the transcription of genes by interacting with retinoic acid response elements within promoter regions, potentially leading to the upregulation of MAGI-1b expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine can induce DNA demethylation, which may lead to the reactivation of epigenetically silenced genes. This agent could hypothetically contribute to the increased transcription of genes like MAGI-1b. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin elevates intracellular cAMP levels, which may activate PKA and subsequently CREB, a transcription factor that could stimulate the expression of a wide array of genes, including potentially MAGI-1b. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
β-Estradiol binds estrogen receptors, which may then bind to estrogen response elements on the DNA, potentially leading to an enhanced transcription of target genes, possibly including MAGI-1b. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor, which can cause chromatin remodeling and increase gene expression by making DNA more accessible for transcription factors, possibly promoting MAGI-1b expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 18 | |
Sodium Butyrate acts as a histone deacetylase inhibitor, potentially leading to an open chromatin structure and increased transcription of certain genes, which may include the gene encoding MAGI-1b. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride can inhibit GSK-3β, potentially leading to stabilization and activation of β-catenin, which may enhance the transcription of Wnt target genes, this could hypothetically include the gene for MAGI-1b. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Cholecalciferol, after conversion to its active form, can bind to the vitamin D receptor, which may interact with vitamin D response elements, possibly stimulating the transcription of certain genes, including those akin to MAGI-1b. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cAMP analog that can activate cAMP-dependent pathways, potentially leading to the activation of transcription factors like CREB and upregulation of genes under their control, potentially including MAGI-1b. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate, known for its antioxidant properties, may also exhibit epigenetic modifying activities, which could influence the transcription machinery to enhance expression of certain genes, potentially including MAGI-1b. | ||||||