MAGE-D4B Inhibitors
MAGE-D4B inhibitors belong to a specialized class of chemical compounds designed to target and modulate the activity of the MAGE-D4B protein. MAGE-D4B, short for Melanoma-associated antigen D4B, is a member of the melanoma-associated antigen (MAGE) family of proteins. These proteins are often associated with various cancers, including melanoma, and are known to play crucial roles in tumorigenesis and cancer progression. Inhibitors specifically designed to target MAGE-D4B are of significant interest in cancer research due to their potential to disrupt the molecular pathways.
The development of MAGE-D4B inhibitors is grounded in the understanding of the protein's role in cancer biology. MAGE-D4B is known to interact with other proteins and participate in cellular processes that contribute to tumor growth and survival. Inhibitors of MAGE-D4B are designed to disrupt these interactions or block the protein's function, ultimately aiming to impede cancer cell proliferation and survival. These inhibitors are typically small molecules or biologics that can bind to MAGE-D4B, altering its conformation or preventing its interaction with critical cellular partners.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Imatinib mesylate | 220127-57-1 | sc-202180 sc-202180A | 25 mg 100 mg | $45.00 $111.00 | 61 | |
Inhibits tyrosine kinase activity, targeting BCR-ABL fusion protein implicated in chronic myeloid leukemia. | ||||||
MDV3100 | 915087-33-1 | sc-364354 sc-364354A | 5 mg 50 mg | $245.00 $1051.00 | 7 | |
Competitively inhibits the androgen receptor, used to block androgen signaling. | ||||||
Osimertinib | 1421373-65-0 | sc-507355 | 5 mg | $86.00 | ||
Irreversibly inhibits EGFR with T790M mutation, used in non-small cell resistant to other EGFR inhibitors. | ||||||
Ibrutinib | 936563-96-1 | sc-483194 | 10 mg | $156.00 | 5 | |
Binds to and inhibits Bruton's tyrosine kinase, used in B-cell malignancies | ||||||
ABT-199 | 1257044-40-8 | sc-472284 sc-472284A sc-472284B sc-472284C sc-472284D | 1 mg 5 mg 10 mg 100 mg 3 g | $118.00 $337.00 $520.00 $832.00 $1632.00 | 10 | |
Selectively inhibits BCL-2, promoting apoptosis in chronic lymphocytic leukemia. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
PARP inhibitor that prevents DNA repair in BRCA-mutated cells | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $321.00 | ||
DK4/6 inhibitor that halts cell cycle progression | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $251.00 $500.00 $547.00 | 16 | |
JAK1/2 inhibitor that reduces inflammation and cell proliferation, used in myelofibrosis and polycythemia vera. | ||||||
CH5424802 | 1256580-46-7 | sc-364461 sc-364461A | 5 mg 50 mg | $191.00 $902.00 | ||
Targets ALK fusion protein in ALK-positive non-small celll inhibiting cell growth. | ||||||
Ribociclib | 1211441-98-3 | sc-507367 | 10 mg | $450.00 | ||
CDK4/6 inhibitor used in combination with hormone therapy halting cell division. | ||||||