MAGE-C2 Activators
MAGE-C2 Activators are a diverse array of chemical compounds that indirectly augment the functional activity of MAGE-C2 by modulating cellular pathways and epigenetic mechanisms. For instance, Resveratrol, by impacting the p53 pathway, could potentially stabilize p53, which in turn may enhance the interaction and activity of MAGE-C2, a protein that modulates p53's transcriptional activity in certain cancer cells. Similarly, histone deacetylase inhibitors like Trichostatin A and Vorinostat alter chromatin structure, which may lead to increased expression of genes like MAGE-C2. DNA methyltransferase inhibitors, including 5-Aza-2'-deoxycytidine and Decitabine, promote the demethylation of gene promoters, potentially upregulating MAGE-C2 expression. Sodium Butyrate, another HDAC inhibitor, may also elevate MAGE-C2 levels by affecting histone acetylation, thus enhancing the immunogenicity of cancer cells.
Additionally, compounds like Disulfiram and Bortezomib influence proteasome activity, with the former potentially enhancing MAGE-C2 peptide presentation on MHC class I molecules and the latter leading to protein accumulation, including that of MAGE-C2, thereby possibly increasing its stability and presence. Meanwhile, epigenetic modulators like Romidepsin and Azacitidine are thought to increase MAGE-C2 activity by changing the methylation status of its gene promoter, leading to enhanced expression. Collectively, these chemical compounds, through their targeted effects on cellular signaling and gene expression, facilitate the enhancement of MAGE-C2 functions related to its role in immunogenicity and possibly its interactions with other proteins involved in oncogenesis, without the need for upregulating its expression through direct activation mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol influences the p53 signaling pathway. MAGE-C2 has been implicated in modulating p53 transcriptional activity. Resveratrol may enhance the activity of MAGE-C2 by stabilizing p53 and promoting its interaction with MAGE-C2. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can affect chromatin structure and gene expression. By altering the acetylation state of histones, it could enhance the expression of genes like MAGE-C2 in cancer cells. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
This DNA methyltransferase inhibitor can lead to the demethylation of gene promoters. By demethylating the promoter region of MAGE-C2, it may increase the expression of MAGE-C2. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate, a short-chain fatty acid, acts as a histone deacetylase inhibitor, potentially increasing the expression of tumor antigens like MAGE-C2 by altering histone acetylation and enhancing immunogenicity. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram can modulate the proteasome activity. It could potentially enhance the presentation of MAGE-C2 peptides on MHC class I molecules, indirectly increasing the functional activity of MAGE-C2 in immune surveillance. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor that can lead to the accumulation of proteins including tumor antigens. This could enhance the functional activity of MAGE-C2 by increasing its stability and presence in cancer cells. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $214.00 $622.00 | 1 | |
Romidepsin is another histone deacetylase inhibitor which may enhance the expression of cancer-testis antigens like MAGE-C2, potentially increasing its activity by epigenetic modulation. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid (Vorinostat), an HDAC inhibitor, can increase the expression of proteins including those in the MAGE family by epigenetic changes, potentially enhancing the functional activity of MAGE-C2. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a nucleoside analog of cytidine, can inhibit DNA methylation. By reducing the methylation of the MAGE-C2 gene promoter, it may enhance the expression and activity of MAGE-C2. | ||||||