MAGE-A8 Activators
MAGE-A8 Activators interact indirectly with cellular pathways to enhance the expression or activity of MAGE-A8. They are typically involved in modulating the stress responses within the cell. For example, Celastrol and Geldanamycin engage the heat shock response elements by inducing HSF1 and inhibiting Hsp90, respectively, which can lead to a broad increase in the expression of heat shock proteins and may inadvertently upregulate MAGE-A8 expression as part of the stress response.
Another subset of these chemicals operates by altering intracellular signaling molecules that regulate gene expression. Compounds like Forskolin and PMA activate cAMP and PKC pathways, respectively, both of which are critical in the regulation of gene transcription. Similarly, compounds like Resveratrol and Betulinic Acid can modulate signaling pathways and transcription factors that control the expression of genes involved in cellular stress responses.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
Celastrol can induce Heat Shock Factor 1 (HSF1), which in turn can activate heat shock proteins and may also lead to the expression of genes including MAGE-A8 as part of the stress response. | ||||||
(±)-Methyl Jasmonate | 39924-52-2 | sc-205386 sc-205386A sc-205386B sc-205386C sc-205386D sc-205386E sc-205386F | 1 g 5 g 10 g 50 g 100 g 500 g 1 kg | $36.00 $105.00 $204.00 $890.00 $1671.00 $7081.00 $12491.00 | ||
It is involved in the jasmonate signaling pathway which is linked to various stress responses in cells and may enhance the expression of certain proteins including those in the MAGE family. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc acts as a cofactor for many transcription factors and may enhance gene expression, including potentially that of MAGE-A8. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
An activator of adenylate cyclase, Forskolin can increase cAMP levels and activate protein kinase A, which may upregulate gene expression, possibly including MAGE-A8. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
An activator of protein kinase C, PMA can influence gene expression through multiple signaling cascades and might enhance the expression of MAGE-A8. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
A compound that can activate sirtuins and modulate gene expression, potentially including the upregulation of certain genes under stress conditions. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
It can induce cellular stress responses that may lead to the activation of various signaling pathways and enhance the expression of stress-response genes. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $108.00 $780.00 | 3 | |
An inducer of oxidative stress, it may cause the upregulation of various protective cellular pathways, which could include MAGE-A8. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $31.00 $117.00 $918.00 | 136 | |
DMSO can induce differentiation and stress responses in cells, leading to changes in gene expression profiles, which may include MAGE-A8. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
It generates oxidative stress, which may result in the activation of various cellular defense mechanisms including the expression of genes like MAGE-A8. | ||||||