mAChR M2 Activators

Arecaidine but-2-ynyl ester tosylate functions as a selective modulator of the M2 muscarinic acetylcholine receptor, exhibiting unique binding dynamics that stabilize receptor conformations. Its distinct steric and electronic properties facilitate specific interactions with the receptor's binding site, influencing downstream signaling cascades. The compound's reactivity profile suggests rapid kinetics in ligand-receptor interactions, potentially leading to nuanced effects on cellular signaling pathways.

Oxotremorine Sesquifumarate acts as a potent modulator of the M2 muscarinic acetylcholine receptor, characterized by its unique ability to induce conformational changes in the receptor. Its molecular structure promotes specific hydrogen bonding and hydrophobic interactions, enhancing receptor affinity. The compound exhibits distinctive reaction kinetics, allowing for rapid dissociation and re-binding, which may influence the receptor's signaling efficiency and overall cellular response.

Milameline hydrochloride functions as a selective modulator of the M2 muscarinic acetylcholine receptor, distinguished by its capacity to stabilize specific receptor conformations. Its unique molecular architecture facilitates intricate electrostatic interactions and pi-stacking, which enhance binding specificity. The compound's kinetic profile reveals a notable propensity for allosteric modulation, potentially altering downstream signaling pathways and influencing receptor dynamics in a nuanced manner.

FP-TZTP functions as a selective modulator of the M2 muscarinic acetylcholine receptor, distinguished by its unique ability to form strong π-π stacking interactions and engage in specific electrostatic interactions with receptor residues. Its molecular architecture facilitates distinct allosteric modulation, leading to altered receptor dynamics and signaling pathways. The compound's reactivity profile showcases rapid kinetics, enabling fine-tuned control over receptor activation and downstream effects.

Carbachol, a cholinergic agonist, directly enhances mAChR M2 by activating its acetylcholine binding site. This leads to increased downstream signaling and a rise in mAChR M2 functional activity.

Pilocarpine, a cholinergic agonist, enhances mAChR M2 by activating its acetylcholine binding site. This activation results in increased downstream signaling and elevated mAChR M2 functional activity.

Oxotremorine methiodide, a cholinergic agonist, directly enhances mAChR M2 by binding to its acetylcholine binding site. This binding activates the receptor, leading to increased downstream signaling and heightened mAChR M2 functional activity.

Arecoline, a cholinergic agonist, enhances mAChR M2 by activating its acetylcholine binding site. This activation triggers downstream signaling, resulting in increased mAChR M2 functional activity.

McN-A-329, a muscarinic receptor agonist, directly enhances mAChR M2 by activating its acetylcholine binding site. This activation triggers downstream signaling, resulting in an increase in mAChR M2 functional activity.

Cevimeline, a cholinergic agonist, enhances mAChR M2 by activating its acetylcholine binding site. This activation leads to increased downstream signaling and elevated mAChR M2 functional activity.