Molecular structure of Milameline hydrochloride, CAS Number: 139886-32-1
Milameline hydrochloride (CAS 139886-32-1)
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Application:
Milameline hydrochloride is a muscarinic receptor agonist
CAS Number:
139886-32-1
Purity:
≥99%
Molecular Weight:
190.67
Molecular Formula:
C8H14N2O•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Muscarinic receptor agonist that displays roughly equal affinity at all receptor subtypes (Ki values are 2.3, 2.4, 3.6, 3.8 and 4.3 μM for hM1, hM2, hM3, hM4 and hM5 receptors respectively). Cognitive enhancer; reverses spatial memory deficits in rats.
Milameline hydrochloride (CAS 139886-32-1) References
- In vitro characterisation of the muscarinic receptor partial agonist, sabcomeline, in rat cortical and heart membranes. | Watson, JM., et al. 1999. Eur J Pharmacol. 370: 69-77. PMID: 10323282
- Functional comparison of muscarinic partial agonists at muscarinic receptor subtypes hM1, hM2, hM3, hM4 and hM5 using microphysiometry. | Wood, MD., et al. 1999. Br J Pharmacol. 126: 1620-4. PMID: 10323594
- Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats. | Shannon, HE., et al. 1999. J Pharmacol Exp Ther. 290: 901-7. PMID: 10411607
- Combining tacrine with milameline reverses a scopolamine-induced impairment of continuous performance in rhesus monkeys. | Callahan, MJ. 1999. Psychopharmacology (Berl). 144: 234-8. PMID: 10435389
- Therapeutic strategies in Alzheimer's disease: M1 muscarinic agonists. | Fisher, A. 2000. Jpn J Pharmacol. 84: 101-12. PMID: 11128032
- Interaction of a muscarinic cholinergic agonist on acetylcholine and dopamine receptors in the monkey brain studied with positron emission tomography. | Hartvig, P., et al. 2002. Dement Geriatr Cogn Disord. 13: 199-204. PMID: 12006729
- Muscarinic receptors as a target for drugs treating schizophrenia. | Bymaster, FP., et al. 2002. Curr Drug Targets CNS Neurol Disord. 1: 163-81. PMID: 12769625
- Pharmacologic interactions between the muscarinic cholinergic and dopaminergic systems in the modulation of prepulse inhibition in rats. | Jones, CK., et al. 2005. J Pharmacol Exp Ther. 312: 1055-63. PMID: 15574685
- Combined cerebral blood flow effects of a cholinergic agonist (milameline) and a verbal recognition task in early Alzheimer's disease. | Trollor, JN., et al. 2006. Psychiatry Clin Neurosci. 60: 616-25. PMID: 16958947
- Effect of novel arecoline thiazolidinones as muscarinic receptor 1 agonist in Alzheimer's dementia models. | Chandra, JN., et al. 2008. Neurochem Int. 52: 376-83. PMID: 17719699
- Effect of novel N-aryl sulfonamide substituted 3-morpholino arecoline derivatives as muscarinic receptor 1 agonists in Alzheimer's dementia models. | Kumar, YC., et al. 2008. Bioorg Med Chem. 16: 5157-63. PMID: 18359231
- Involvement of the cholinergic system in conditioning and perceptual memory. | Robinson, L., et al. 2011. Behav Brain Res. 221: 443-65. PMID: 21315109
- Muscarinic receptor pharmacology and circuitry for the modulation of cognition. | Bubser, M., et al. 2012. Handb Exp Pharmacol. 121-66. PMID: 22222698
- Acute modulation of the cholinergic system in the mouse brain detected by pharmacological resting-state functional MRI. | Shah, D., et al. 2015. Neuroimage. 109: 151-9. PMID: 25583611
Activator of:
mAChR M1, mAChR M2, mAChR M3, mAChR M4, and mAChR M5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Milameline hydrochloride, 10 mg | sc-204085 | 10 mg | $140.00 | |||
Milameline hydrochloride, 50 mg | sc-204085A | 50 mg | $575.00 |