Molecular structure of FP-TZTP, CAS Number: 424829-90-3
FP-TZTP (CAS 424829-90-3)
Application:
FP-TZTP is an mAChR M2 (M2 selective muscarinic) agonist
CAS Number:
424829-90-3
Molecular Weight:
273.39
Molecular Formula:
C11H16FN3S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
FP-TZTP is an mAChR M2 (M2 selective muscarinic) agonist that may allow noninvasive studies of Alzheimer′s disease with PET.
FP-TZTP (CAS 424829-90-3) References
- Identification of metabolites of fluorine-18-labeled M2 muscarinic receptor agonist, 3-(3-[(3-fluoropropyl)thio]-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-methylpyridine, produced by human and rat hepatocytes. | Ma, Y., et al. 2002. J Chromatogr B Analyt Technol Biomed Life Sci. 766: 319-29. PMID: 11824820
- Theory and practice of imaging saturable binding sites. | Eckelman, WC., et al. 2002. Invest Radiol. 37: 101-6. PMID: 11882788
- Application of LC-MS to the analysis of new radiopharmaceuticals. | Ma, Y., et al. 2003. Mol Imaging Biol. 5: 397-403. PMID: 14667494
- The use of gene-manipulated mice in the validation of receptor binding radiotracer. | Eckelman, WC. 2003. Nucl Med Biol. 30: 851-60. PMID: 14698789
- Synthesis and evaluation of iodinated TZTP-derivatives as potential radioligands for imaging of muscarinic M2 receptors with SPET. | Knol, RJ., et al. 2004. Nucl Med Biol. 31: 111-23. PMID: 14741576
- Why does the agonist [(18)F]FP-TZTP bind preferentially to the M(2) muscarinic receptor? | Ravasi, L., et al. 2006. Eur J Nucl Med Mol Imaging. 33: 292-300. PMID: 16333673
- Imaging of muscarinic receptors in the central nervous system. | Eckelman, WC. 2006. Curr Pharm Des. 12: 3901-13. PMID: 17073686
- Evaluation of [18F]fluoroxanomeline {5-{4-[(6-[18F]fluorohexyl)oxy]-1,2,5-thiadiazol-3-yl}-1-methyl-1,2,3,6-tetrahydropyridine} in muscarinic knockout mice. | Kiesewetter, DO., et al. 2007. Nucl Med Biol. 34: 141-52. PMID: 17307122
- Comparison of the pharmacokinetics of different analogs of 11C-labeled TZTP for imaging muscarinic M2 receptors with PET. | Reid, AE., et al. 2008. Nucl Med Biol. 35: 287-98. PMID: 18355684
- Applications of LC-MS in PET radioligand development and metabolic elucidation. | Ma, Y., et al. 2010. Curr Drug Metab. 11: 483-93. PMID: 20540692
- Synthesis and in vitro evaluation of novel nortropane derivatives as potential radiotracers for muscarinic m(2) receptors. | Knol, RJ., et al. 2011. Int J Mol Imaging. 2011: 709416. PMID: 21755053
- Striatal dopamine D1-like receptor binding is unchanged in primary focal dystonia. | Karimi, M., et al. 2013. Mov Disord. 28: 2002-6. PMID: 24151192
- Preparation of 18F-labeled muscarinic agonist with M2 selectivity. | Kiesewetter, DO., et al. 1995. J Med Chem. 38: 5-8. PMID: 7837240
- Muscarinic cholinergic receptor measurements with [18F]FP-TZTP: control and competition studies. | Carson, RE., et al. 1998. J Cereb Blood Flow Metab. 18: 1130-42. PMID: 9778190
Activator of:
mAChR M2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FP-TZTP, 5 mg | sc-211543 | 5 mg | $280.00 | |||
FP-TZTP, 25 mg | sc-211543A | 25 mg | $1105.00 |