Arecoline (CAS 63-75-2)
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Arecoline is a natural alkaloid and is the subject of research in various fields of biochemistry and neurobiology due to its activity as a muscarinic acetylcholine receptor agonist. The compound′s ability to bind to and activate these receptors makes it a useful tool for studying the cholinergic system, which is involved in a wide range of physiological processes including memory, cognition, and muscle contraction. Researchers investigate the effects of arecoline on neurotransmission, exploring its potential to modulate synaptic plasticity and neural circuitry. Additionally, the compound is used in studies that aim to understand the effects of cholinergic stimulation on various organ systems. In agricultural research, arecoline′s impact on the nervous system of parasites is of interest.
Arecoline (CAS 63-75-2) References
- The pharmacology, toxicology and potential applications of arecoline: a review. | Liu, YJ., et al. 2016. Pharm Biol. 54: 2753-2760. PMID: 27046150
- Arecoline inhibits pineal-testis function in experimentally induced hypothyroid rats. | Saha, I., et al. 2020. Arch Physiol Biochem. 126: 7-16. PMID: 30145920
- DARK Classics in Chemical Neuroscience: Arecoline. | Volgin, AD., et al. 2019. ACS Chem Neurosci. 10: 2176-2185. PMID: 30664352
- A Review on Role of Arecoline and Its Metabolites in the Molecular Pathogenesis of Oral Lesions with an Insight into Current Status of Its Metabolomics. | Das, A. and Giri, S. 2020. Prague Med Rep. 121: 209-235. PMID: 33270010
- Arecoline induces epithelial-mesenchymal transformation and promotes metastasis of oral cancer by SAA1 expression. | Ren, H., et al. 2021. Cancer Sci. 112: 2173-2184. PMID: 33626219
- The molecular mechanisms underlying arecoline-induced cardiac fibrosis in rats. | Ku, CW., et al. 2021. Open Life Sci. 16: 1182-1192. PMID: 34761109
- Arecoline induces cardiotoxicity by upregulating and activating cardiac hypertrophy-related pathways in Sprague-Dawley rats. | Ho, TJ., et al. 2022. Chem Biol Interact. 354: 109810. PMID: 34999050
- N6-methyladenosine modification contributes to arecoline-mediated oral submucosal fibrosis. | Li, X., et al. 2022. J Oral Pathol Med. 51: 474-482. PMID: 35377493
- Hydrogen sulfide prevents arecoline-induced neurotoxicity via promoting leptin/leptin receptor signaling pathway. | Cheng, X., et al. 2022. Cell Biol Int. 46: 1355-1366. PMID: 35819076
- Arecoline promotes proliferation and migration of human HepG2 cells through activation of the PI3K/AKT/mTOR pathway. | Xie, H., et al. 2022. Hereditas. 159: 29. PMID: 35836300
- Arecoline Is Associated With Inhibition of Cuproptosis and Proliferation of Cancer-Associated Fibroblasts in Oral Squamous Cell Carcinoma: A Potential Mechanism for Tumor Metastasis. | Li, J., et al. 2022. Front Oncol. 12: 925743. PMID: 35875097
- N-acetyl cysteine prevents arecoline-inhibited C2C12 myoblast differentiation through ERK1/2 phosphorylation. | Li, YX., et al. 2022. PLoS One. 17: e0272231. PMID: 35901044
- Systematic Review of Roles of Arecoline and Arecoline N-Oxide in Oral Cancer and Strategies to Block Carcinogenesis. | Ko, AM., et al. 2023. Cells. 12: PMID: 37190117
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Arecoline, 10 mg | sc-210836 | 10 mg | $153.00 |