mAChR M1 Activators
SEE ALSO...
Items 1 to 10 of 13 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cevimeline Hydrochloride Salt | 107220-28-0 | sc-207420 | 5 mg | $330.00 | ||
Cevimeline Hydrochloride Salt acts as a potent agonist at the M1 muscarinic acetylcholine receptor, characterized by its ability to induce specific allosteric changes in receptor conformation. This compound engages in unique electrostatic interactions with key amino acid residues, enhancing receptor activation. Its distinct pharmacokinetic properties allow for rapid receptor binding and prolonged activity, influencing intracellular signaling cascades and promoting nuanced physiological responses. | ||||||
cis-2-Methyl-5-trimethylammoniummethyl-1,3-oxathiolane iodide | 76541-57-6 | sc-252614 | 5 mg | $199.00 | ||
Cis-2-Methyl-5-trimethylammoniummethyl-1,3-oxathiolane iodide functions as a selective modulator of the M1 muscarinic acetylcholine receptor, exhibiting unique ligand-receptor dynamics. Its quaternary ammonium structure facilitates strong ionic interactions with the receptor, promoting a specific conformational shift. This compound's kinetic profile reveals a rapid association and dissociation rate, allowing for fine-tuned modulation of downstream signaling pathways, thereby influencing cellular responses with precision. | ||||||
N-Desmethylclozapine | 6104-71-8 | sc-201113 sc-201113A | 5 mg 25 mg | $98.00 $364.00 | 2 | |
N-Desmethylclozapine acts as a modulator of the M1 muscarinic acetylcholine receptor, characterized by its ability to engage in unique hydrogen bonding interactions. This compound exhibits a distinct allosteric effect, altering receptor conformation and enhancing ligand affinity. Its interaction kinetics are notable for a prolonged duration of action, which may lead to sustained receptor activation. Additionally, its lipophilicity contributes to effective membrane permeability, influencing its bioavailability in cellular environments. | ||||||
Oxotremorine Sesquifumarate | 17360-35-9 | sc-200170 sc-200170A | 100 mg 500 mg | $66.00 $255.00 | ||
Oxotremorine Sesquifumarate selectively targets the M1 muscarinic acetylcholine receptor, showcasing a unique binding profile that stabilizes receptor states. Its interaction involves specific electrostatic and hydrophobic contacts, facilitating a nuanced modulation of signaling pathways. The compound exhibits rapid kinetics, allowing for swift receptor activation, while its structural features promote effective integration into lipid bilayers, enhancing its interaction with cellular membranes. | ||||||
Milameline hydrochloride | 139886-32-1 | sc-204085 sc-204085A | 10 mg 50 mg | $137.00 $564.00 | 1 | |
Milameline hydrochloride exhibits a distinctive affinity for the M1 muscarinic acetylcholine receptor, characterized by its ability to induce conformational changes that enhance receptor activity. The compound engages in specific hydrogen bonding and hydrophobic interactions, which fine-tune downstream signaling cascades. Its kinetic profile reveals a balanced rate of receptor binding and dissociation, allowing for sustained modulation of cholinergic pathways, while its solubility properties facilitate effective cellular uptake. | ||||||
tert-Butyl peroxybenzoate | 614-45-9 | sc-258210 | 100 ml | $38.00 | ||
Allosteric agonist, selectively activates M1 receptors enhancing receptor response to acetylcholine. | ||||||
Xanomeline oxalate | 141064-23-5 | sc-204402 | 10 mg | $155.00 | ||
Xanomeline oxalate selectively targets the M1 muscarinic acetylcholine receptor, demonstrating unique allosteric modulation that alters receptor dynamics. Its molecular structure allows for intricate electrostatic interactions and pi-stacking with aromatic residues, enhancing receptor activation. The compound exhibits a rapid association rate with the receptor, coupled with a prolonged dissociation phase, promoting persistent signaling. Additionally, its solubility characteristics support efficient membrane permeability, influencing bioavailability. | ||||||
VU 0357017 hydrochloride | 1135242-13-5 | sc-362818 sc-362818A | 5 mg 25 mg | $90.00 $364.00 | ||
VU 0357017 hydrochloride is a selective modulator of the M1 muscarinic acetylcholine receptor, exhibiting unique binding kinetics that facilitate receptor activation. Its structural conformation enables specific hydrogen bonding and hydrophobic interactions with key amino acid residues, enhancing receptor affinity. The compound's dynamic behavior includes a fast onset of action, followed by a gradual dissociation, which sustains receptor engagement. Furthermore, its physicochemical properties contribute to favorable membrane interactions, optimizing its functional profile. | ||||||
McN-A-343 | 55-45-8 | sc-200186A sc-200186 | 10 mg 50 mg | $26.00 $77.00 | 4 | |
McN-A-343 is a potent allosteric modulator of the M1 muscarinic acetylcholine receptor, characterized by its ability to stabilize receptor conformations that promote signaling. It engages in specific electrostatic interactions with charged residues, enhancing receptor selectivity. The compound exhibits a unique dual-action mechanism, facilitating both receptor activation and desensitization. Its lipophilic nature aids in membrane penetration, influencing its pharmacokinetic behavior and receptor modulation efficiency. | ||||||
(2S)-2-Ethyl-8-methyl-1-thia-4,8-diazaspiro[4,5]decan-3-one | 503431-81-0 | sc-206582 | 5 mg | $330.00 | ||
(2S)-2-Ethyl-8-methyl-1-thia-4,8-diazaspiro[4,5]decan-3-one acts as a selective modulator of the M1 muscarinic acetylcholine receptor, exhibiting unique binding dynamics that favor specific receptor conformations. Its structural features allow for intricate hydrogen bonding and hydrophobic interactions, enhancing receptor affinity. The compound's spirocyclic framework contributes to its distinct conformational flexibility, influencing its interaction kinetics and overall receptor modulation profile. | ||||||