Date published: 2025-10-15

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Ly-6D Inhibitors

Chemical inhibitors of Ly-6D can act through various molecular pathways to achieve functional inhibition of this protein. Phorbol 12-myristate 13-acetate (PMA) and Staurosporine work through modulation of protein kinase C (PKC). Staurosporine, by inhibiting PKC, prevents the phosphorylation and subsequent activation of Ly-6D. Genistein, a tyrosine kinase inhibitor, and Dasatinib, a Src family kinase inhibitor, both prevent phosphorylation required for the activity of Ly-6D; thus, their action leads to its functional inhibition. LY294002 and Wortmannin, both PI3K inhibitors, suppress the PI3K/Akt pathway that can regulate Ly-6D activity, resulting in decreased function of the protein. Furthermore, U0126 and PD98059, both MEK inhibitors, reduce the activation of the ERK pathway, which could be necessary for the functional activity of Ly-6D. SB203580 targets the p38 MAPK pathway, and SP600125 inhibits JNK, both of which are part of the MAPK signaling cascade; inhibition of these pathways can lead to a decrease in Ly-6D activity. Rapamycin's role as an mTOR inhibitor also affects the PI3K/Akt pathway, further contributing to the functional inhibition of Ly-6D by preventing necessary downstream signaling. PP2, another Src family tyrosine kinase inhibitor, reduces Src kinase-mediated phosphorylation events that are potentially crucial for Ly-6D's activity.

Items 1 to 10 of 11 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Staurosporine

62996-74-1sc-3510
sc-3510A
sc-3510B
100 µg
1 mg
5 mg
$82.00
$150.00
$388.00
113
(4)

Staurosporine is a potent inhibitor of protein kinases, including PKC. By inhibiting PKC, it prevents the phosphorylation of Ly-6D, thereby inhibiting its function.

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$26.00
$92.00
$120.00
$310.00
$500.00
$908.00
$1821.00
46
(1)

Genistein is a tyrosine kinase inhibitor. As Ly-6D may require phosphorylation for its activity, the inhibition of tyrosine kinases can prevent its activation state, leading to functional inhibition.

Dasatinib

302962-49-8sc-358114
sc-358114A
25 mg
1 g
$47.00
$145.00
51
(1)

Dasatinib is a Src family kinase inhibitor. Since Src kinase activity can be involved in regulating Ly-6D function, its inhibition can lead to a decrease in Ly-6D activity.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

LY294002 is a PI3K inhibitor, and PI3K signaling can regulate multiple proteins including Ly-6D. Inhibition of PI3K can reduce the activity of downstream signaling pathways necessary for Ly-6D function.

U-0126

109511-58-2sc-222395
sc-222395A
1 mg
5 mg
$63.00
$241.00
136
(2)

U0126 is an inhibitor of MEK1/2, which are upstream of ERK in the MAPK pathway. As the MAPK pathway can regulate protein functions, including Ly-6D, its inhibition can suppress Ly-6D activity.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$88.00
$342.00
284
(5)

SB203580 is a p38 MAPK inhibitor, and p38 MAPK can regulate various protein functions, including those of Ly-6D. Inhibition of p38 MAPK can therefore lead to functional inhibition of Ly-6D.

SP600125

129-56-6sc-200635
sc-200635A
10 mg
50 mg
$40.00
$150.00
257
(3)

SP600125 is an inhibitor of JNK, which is part of the MAPK pathway. By inhibiting JNK, it may prevent the functional activation of Ly-6D that relies on JNK-mediated signaling.

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$66.00
$219.00
$417.00
97
(3)

Wortmannin is a PI3K inhibitor that can suppress the PI3K/Akt pathway, a possible regulator of Ly-6D. Inhibition of this pathway can prevent the activation and function of Ly-6D.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$62.00
$155.00
$320.00
233
(4)

Rapamycin inhibits mTOR, which is part of the PI3K/Akt pathway. By inhibiting mTOR, Rapamycin can prevent the downstream signaling that may be required for the full functionality of Ly-6D.

PP 2

172889-27-9sc-202769
sc-202769A
1 mg
5 mg
$92.00
$223.00
30
(1)

PP2 is an Src family tyrosine kinase inhibitor. Inhibiting Src kinases can decrease the phosphorylation and subsequent activity of proteins like Ly-6D that may depend on Src signaling.