LRRC69 Activators
Chemical activators of leucine rich repeat containing 69 can influence the protein's state through various intracellular signaling pathways. Anisomycin, as an activator of stress-activated protein kinases, can initiate a cascade of phosphorylation events that enhance the activity of leucine rich repeat containing 69. Similarly, Bryostatin 1, by modulating protein kinase C (PKC), can indirectly lead to the activation of this protein through PKC-dependent mechanisms. Bisindolylmaleimide I, while generally known as a PKC inhibitor, can under certain conditions act to promote PKC activity, thereby affecting the phosphorylation status and activity of leucine rich repeat containing 69. Hydrogen peroxide serves as a signaling molecule, influencing various kinases and phosphatases, which can lead to the activation of leucine rich repeat containing 69 through oxidative signaling pathways. Lithium Chloride can impinge upon Wnt/β-catenin signaling, potentially leading to leucine rich repeat containing 69 activation through the inhibition of GSK-3β and subsequent kinase activation.
Furthermore, the chemical LY294002, although a PI3K inhibitor, can lead to the compensatory activation of other kinases such as AKT, which can influence the activation state of leucine rich repeat containing 69. MG132, by inhibiting proteasome activity, can lead to the buildup of ubiquitinated proteins, thereby affecting various signaling pathways and possibly the activation state of leucine rich repeat containing 69. PD98059 and SB203580, which are inhibitors of the ERK pathway and p38 MAP kinase respectively, can lead to the activation of alternate signaling pathways that impact the activity of leucine rich repeat containing 69 through stress response mechanisms or feedback loops. Lastly, Staurosporine, although a potent kinase inhibitor, can under specific conditions lead to the activation of kinases by inducing a stress response, potentially resulting in the activation of leucine rich repeat containing 69 through phosphorylation cascades. Each of these chemicals can alter the phosphorylation landscape within cells, thereby modulating the activity of leucine rich repeat containing 69.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a potent activator of the stress-activated protein kinases (SAPKs)/Jun amino-terminal kinases (JNKs), which may lead to the activation of leucine rich repeat containing 69 through phosphorylation events within its signaling pathways. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a specific inhibitor of protein kinase C (PKC), but it can paradoxically act as an activator of PKC isoforms under certain conditions, potentially leading to the activation of leucine rich repeat containing 69 via PKC-dependent signaling mechanisms. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $240.00 | 9 | |
Bryostatin 1 is a modulator of protein kinase C (PKC) which can activate PKC isoforms, potentially resulting in the activation of leucine rich repeat containing 69 through downstream phosphorylation pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG can influence multiple signaling pathways, including those involving the 67 kDa laminin receptor, which has been implicated in cellular signaling related to leucine rich repeat containing 69 activation. | ||||||
Fumonisin B1 | 116355-83-0 | sc-201395 sc-201395A | 1 mg 5 mg | $117.00 $469.00 | 18 | |
Fumonisin B1 inhibits ceramide synthase, causing alterations in sphingolipid metabolism and potentially activating leucine rich repeat containing 69 by affecting sphingolipid-dependent signaling pathways. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
Hydrogen peroxide functions as a signaling molecule that can activate various kinases and phosphatases, which can lead to the activation of leucine rich repeat containing 69 through oxidative signaling pathways. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride can activate the Wnt/β-catenin signaling pathway, which might lead to the activation of leucine rich repeat containing 69 via GSK-3β inhibition and downstream kinase activation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can lead to compensatory activation of other pathways, such as AKT, which could activate leucine rich repeat containing 69 as part of a feedback mechanism. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor that can lead to the accumulation of ubiquitinated proteins, affecting several signaling pathways and potentially leading to the activation of leucine rich repeat containing 69 through non-degradative signaling roles of ubiquitination. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an ERK pathway inhibitor, but it can lead to the compensatory activation of parallel pathways that could result in the activation of leucine rich repeat containing 69 through cross-talk or feedback loops. | ||||||