LRRC6 Activators
Chemicals that fall into the category of LRRC6 Activators are characterized by their ability to modulate various cellular processes and signaling pathways that could indirectly affect the function and expression of LRRC6. Given LRRC6's role in dynein arm assembly necessary for functional cilia, compounds that enhance ciliogenesis or promote the transcription of ciliary genes could be considered as indirect activators. Molecules like retinoic acid and its precursor, all-trans retinol, exert their influence through gene transcription modulation, leading to the upregulation of LRRC6 and consequently promoting the assembly of cilia. Lithium chloride and forskolin impact signaling pathways that intersect with ciliary dynamics; lithium chloride does this through the modulation of the Wnt/GSK-3 pathway, while forskolin raises cAMP levels that can affect ciliary beat frequency and assembly.
On the epigenetic front, compounds such as 5-Azacytidine and trichostatin A are capable of altering gene expression profiles, which could lead to an increase in LRRC6 levels. These agents modify the DNA and histone components, respectively, to create a transcriptionally permissive environment. Trace elements such as manganese and zinc serve as critical cofactors, without which the protein machinery involved in ciliogenesis and associated processes could be compromised. Moreover, small molecules such as EGCG possess broad activity profiles affecting multiple pathways, including those related to oxidative stress and ciliogenesis, which could conceivably intersect with LRRC6's sphere of influence.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Influences gene expression by acting on retinoic acid receptors, which can lead to an upregulation of LRRC6 transcription. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Modulates the Wnt signaling pathway by inhibiting GSK-3, which can indirectly increase ciliogenesis and potentially affect LRRC6 function as it is involved in the formation of cilia. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylate cyclase, raising intracellular cAMP levels, which can promote ciliary beat frequency and potentially enhance the assembly of dynein arms, where LRRC6 plays a role. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $31.00 | ||
Provides manganese, a cofactor for many enzymes, which can indirectly influence LRRC6 by affecting the cellular processes that rely on metalloenzymes, potentially impacting ciliogenesis and LRRC6 function. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
A catechin found in green tea that can modulate multiple signaling pathways and could potentially influence ciliogenesis and LRRC6 function through antioxidant effects or by modulating gene expression. | ||||||
Vitamin A | 68-26-8 | sc-280187 sc-280187A | 1 g 10 g | $385.00 $2654.00 | ||
A vitamin that can be converted to retinoic acid in vivo, influencing gene expression and potentially increasing LRRC6 transcription as part of the regulation of ciliogenesis. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that can lead to hypomethylation of DNA and upregulation of genes, which could include LRRC6, thereby potentially influencing its expression and function. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
A histone deacetylase inhibitor which can lead to a more open chromatin structure and increased gene expression, potentially including LRRC6, thereby affecting its role in dynein arm assembly. | ||||||
L-3,3′,5-Triiodothyronine, free acid | 6893-02-3 | sc-204035 sc-204035A sc-204035B | 10 mg 100 mg 250 mg | $41.00 $77.00 $153.00 | ||
Thyroid hormone that can regulate gene expression and has been shown to affect ciliogenesis, which may influence the function of LRRC6 in dynein arm assembly. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
In low concentrations can act as a signaling molecule, potentially affecting pathways related to ciliogenesis and dynein arm assembly, thereby influencing LRRC6 function. | ||||||