LRRC26 Activators
LRRC26 Activators comprise a selection of chemical compounds that indirectly promote the functional activity of LRRC26 through various signaling pathways. Compounds like Phorbol 12-myristate 13-acetate (PMA) and Forskolin amplify signaling cascades that involve protein kinase C and protein kinase A, respectively. PKC and PKA phosphorylate numerous proteins, potentially including LRRC26 or associated proteins, thereby modulating potassium channel function and enhancing the regulatory roleof LRRC26 in these channels. Similarly, 1-Ethyl-2-benzimidazolinone (1-EBIO) and CyPPA, known for their activation of small conductance Ca2+-activated K+ channels, might indirectly augment LRRC26's activity by triggering downstream Ca2+-sensitive pathways that LRRC26 could be a part of. Ionomycin and Bay K8644, which act by increasing intracellular calcium levels, could also engage LRRC26 in calcium-dependent regulatory mechanisms, thereby potentiating its effect on potassium channel conductance. On the other hand, compounds like NS1643 and NS5806, which directly activate certain potassium channels, could serve to enhance LRRC26's activity by upregulating the channels it may interact with, leading to a synergistic effect on channel activity.
The action of dibutyryl cyclic AMP (db-cAMP) further exemplifies this indirect activation, as its role in PKA activation could phosphorylate and thus enhance the activity of LRRC26. DC-EBIO and NS11021, by targeting Ca2+-activated K+ channels, suggest a similar potential to increase LRRC26's activity through modulation of calcium sensitivity. ML277's selectivity for Kv7.1 channels presents a scenario where, LRRC26 were to modulate this type of channel, its activity could be enhanced by the action of ML277. Collectively, these chemical activators, through their targeted effects on various cellular signaling pathways and ion channel modulation, are poised to facilitate the enhancement of LRRC26's regulatory functions without the need for direct binding or upregulation of gene expression, thereby representing a spectrum of potential mechanisms for increasing LRRC26 activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a diacylglycerol (DAG) analog that activates protein kinase C (PKC). PKC activation leads to the phosphorylation of various proteins, which can include ion channel regulatory subunits. The phosphorylation state of LRRC26 could be modified by such PKC-mediated signaling, enhancing its activity as a regulatory subunit for potassium channels. | ||||||
1-EBIO | 10045-45-1 | sc-201695 sc-201695A | 10 mg 50 mg | $87.00 $325.00 | 1 | |
1-EBIO is a small molecule that enhances the activity of small conductance Ca2+-activated K+ (SK) channels. While LRRC26 is not known to associate with SK channels, the engagement of similar Ca2+-dependent mechanisms could enhance the functional activity of LRRC26-associated potassium channels. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an adenylyl cyclase activator that increases the intracellular cyclic AMP (cAMP) levels, which in turn activates PKA. PKA can phosphorylate a range of proteins, potentially including LRRC26, thereby enhancing its regulatory role in potassium channel function. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which could activate Ca2+-sensitive proteins and pathways. Such a rise in calcium could indirectly enhance the activity of LRRC26 if it is involved in Ca2+-sensitive potassium channel regulation. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $84.00 $196.00 $817.00 | ||
Bay K8644 is an L-type calcium channel activator. By increasing Ca2+ influx, it could indirectly enhance LRRC26 activity if LRRC26 is part of a Ca2+-sensitive potassium channel complex. | ||||||
Calcium dibutyryladenosine cyclophosphate | 362-74-3 | sc-482205 | 25 mg | $147.00 | ||
db-cAMP is a cell-permeable cAMP analog that activates PKA. PKA-mediated phosphorylation could enhance the activity of LRRC26 by modulating its interaction with potassium channels. | ||||||
NS 1643 | 448895-37-2 | sc-204135 sc-204135A | 10 mg 50 mg | $123.00 $473.00 | 3 | |
NS11021 is a selective activator of the large conductance Ca2+-activated K+ (BK) channels. By stabilizing the open state of BK channels, it could also enhance LRRC26 activity if LRRC26 modulates BK channel function. | ||||||