LRRC17 Activators
Leucine-rich repeat-containing 17 (LRRC17) is a protein encoded by the LRRC17 gene in humans. Characterized by its leucine-rich repeat (LRR) domain, LRRC17 is part of a larger family of proteins known for their involvement in protein-protein interactions and their contribution to a variety of cellular functions, including signal transduction and cell adhesion.
LRRC17 has been most notably studied in the context of bone biology. It is recognized as a regulator of osteoclastogenesis, the process by which osteoclasts, the bone-resorbing cells, differentiate and become active. LRRC17 acts as a negative regulator, meaning it inhibits the formation of osteoclasts, thereby playing a protective role in maintaining bone density and blocking excessive bone loss.The expression of LRRC17 is thought to be influenced by various signaling pathways that are critical to bone metabolism, including those activated by mechanical stress, hormonal changes, and inflammatory cytokines. Its role in bone homeostasis suggests that alterations in LRRC17 expression or function could be implicated in bone-related disorders, such as osteoporosis, where the balance between bone formation and resorption is disrupted.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
May regulate gene expression through retinoic acid receptors, influencing bone metabolism. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Increases cAMP levels, which may activate PKA and influence transcription factors that regulate bone-related genes. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
As a histone deacetylase inhibitor, it can lead to chromatin remodeling and affect gene transcription, possibly including LRRC17. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that can cause gene demethylation and activation, potentially affecting LRRC17 expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Another histone deacetylase inhibitor that can affect gene expression by altering chromatin structure. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
May modulate gene expression through epigenetic changes and has been implicated in bone metabolism. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Influences Wnt signaling, which is involved in bone formation and could potentially affect LRRC17 expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C, which may lead to transcriptional regulation of genes involved in bone homeostasis. | ||||||
Sodium Salicylate | 54-21-7 | sc-3520 sc-3520A sc-3520B sc-3520C | 1 g 25 g 500 g 1 kg | $10.00 $26.00 $82.00 $139.00 | 8 | |
Can modulate NF-kB signaling, potentially influencing the transcription of genes involved in bone metabolism. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Known to affect transcription factors and signaling pathways, which may alter gene expression profiles including that of LRRC17. | ||||||