LRIF Activators
LRIF Activators encompass a range of compounds that indirectly engage the protein by modulating the activity of nuclear receptors or transcriptional processes that LRIF1 is associated with. These activators work not by binding to LRIF1 directly but by altering the cellular milieu in which LRIF1 operates, thereby influencing its activity. These chemical activators can initiate their effects through the interaction with various nuclear receptors such as glucocorticoid receptors, peroxisome proliferator-activated receptors, liver X receptors, and retinoic acid receptors, each of which can control the expression of a myriad of genes and regulate LRIF1's function.
The activation of these receptors by the respective compounds results in the modulation of gene expression patterns that are part of LRIF1's regulatory network. For instance, glucocorticoid receptor activation by dexamethasone can result in an altered transcriptional response that may impinge on the function of LRIF1, while retinoic acid's engagement with its receptors can lead to changes in transcription that influence LRIF1 activity. Similarly, agonists of PPAR subtypes like pioglitazone and fenofibrate orchestrate a transcriptional program associated with metabolic processes that LRIF1 may influence. The actions of these compounds can extend to the alteration of lipid metabolism and homeostasis, as seen with compounds like T0901317 and GW501516, which target LXR and PPARδ, respectively.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
A synthetic glucocorticoid that activates glucocorticoid receptors, which can lead to an altered transcriptional response of genes involved in inflammation and metabolism, potentially influencing the activity of LRIF1 in the process. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
A metabolite of Vitamin A that activates retinoic acid receptors, modulating gene expression. This activation can influence LRIF1 activity by altering the transcription of genes that interact with or regulate the function of LRIF1. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
An agonist of the peroxisome proliferator-activated receptor gamma (PPARγ) that modulates the transcription of insulin-sensitive genes and could impact LRIF1 by affecting the transcriptional programs within which LRIF1 may play a role. | ||||||
Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) | 10417-94-4 | sc-200766 sc-200766A | 100 mg 1 g | $102.00 $423.00 | ||
A fatty acid that can act as a ligand for PPAR receptors and influence gene expression patterns, possibly affecting the activity of proteins such as LRIF1 involved in these pathways. | ||||||
Lithocholic acid | 434-13-9 | sc-215262 sc-215262A | 10 g 25 g | $83.00 $272.00 | 1 | |
A secondary bile acid that can activate nuclear receptors like the farnesoid X receptor (FXR), influencing genes involved in bile acid regulation, which could in turn modulate LRIF1 activity. | ||||||
T 0901317 | 293754-55-9 | sc-202824 sc-202824A | 10 mg 50 mg | $87.00 $220.00 | 5 | |
A synthetic ligand for the liver X receptor (LXR) that influences the expression of genes involved in lipid metabolism, potentially affecting LRIF1 through alterations in transcriptional processes. | ||||||
GW501516 | 317318-70-0 | sc-202642 sc-202642A | 1 mg 5 mg | $80.00 $175.00 | 28 | |
A PPARδ agonist that can modify the transcription of various metabolic genes, which might impact LRIF1's involvement in these pathways. | ||||||
25-Hydroxycholesterol | 2140-46-7 | sc-214091B sc-214091 sc-214091A sc-214091C | 5 mg 10 mg 25 mg 100 mg | $52.00 $89.00 $166.00 $465.00 | 8 | |
An oxysterol that can activate LXR, potentially affecting transcriptional regulation and thus LRIF1's activity in lipid homeostasis and metabolism. | ||||||
9-cis-Retinoic acid | 5300-03-8 | sc-205589 sc-205589B sc-205589C sc-205589D sc-205589A | 1 mg 25 mg 250 mg 500 mg 5 mg | $70.00 $416.00 $3060.00 $5610.00 $145.00 | 10 | |
A pan-retinoic acid receptor agonist that can modulate gene expression broadly, with potential effects on the transcriptional processes where LRIF1 is implicated. | ||||||
CHOLESTYRAMINE RESIN | 11041-12-6 | sc-507509 | 5 g | $210.00 | ||
A bile acid sequestrant that indirectly influences nuclear receptor activity by reducing bile acid levels, potentially affecting nuclear receptor-mediated gene expression and LRIF1 activity. | ||||||