LRAT Inhibitors
The inhibitors listed above primarily target various aspects of vitamin A metabolism, which could indirectly influence LRAT activity. Given LRAT's critical role in the esterification of retinol, modulation of retinoid metabolism pathways is relevant for understanding its function and potential regulation.
Retinoids such as Tretinoin, Isotretinoin, Acitretin, Bexarotene, Fenretinide, and Alitretinoin can alter the systemic levels and metabolism of vitamin A, potentially impacting LRAT's enzymatic activity. Citral and Disulfiram, by inhibiting enzymes involved in retinoid metabolism, might indirectly affect the function of LRAT. Citrus flavonoids and dietary depletion of vitamin A can modulate the availability of vitamin A and its metabolites, potentially influencing LRAT activity. ATRA, a key metabolite in the vitamin A pathway, and inhibitors of retinol binding proteins, can regulate retinoid signaling and availability, potentially impacting LRAT's role in retinol metabolism.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Tretinoin, a derivative of vitamin A, can alter retinoid metabolism and potentially influence LRAT's role in retinol processing. | ||||||
13-cis-Retinoic acid | 4759-48-2 | sc-205568 sc-205568A | 100 mg 250 mg | $75.00 $120.00 | 8 | |
Isotretinoin, another vitamin A derivative, may impact retinol metabolism and indirectly affect LRAT activity. | ||||||
Acitretin | 55079-83-9 | sc-210754 | 25 mg | $151.00 | 1 | |
Acitretin, a retinoid, can modify the systemic levels of vitamin A derivatives, potentially impacting LRAT function. | ||||||
Bexarotene | 153559-49-0 | sc-217753 sc-217753A | 10 mg 100 mg | $55.00 $250.00 | 6 | |
Bexarotene, a retinoid X receptor agonist, might influence vitamin A metabolism and indirectly affect LRAT. | ||||||
4-Hydroxyphenylretinamide | 65646-68-6 | sc-200900 sc-200900A | 5 mg 25 mg | $104.00 $315.00 | ||
Fenretinide, a synthetic retinoid, may interact with retinoid metabolism pathways, potentially impacting LRAT activity. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral, an inhibitor of retinaldehyde dehydrogenase, might indirectly affect LRAT by altering retinoid metabolism. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram can inhibit aldehyde dehydrogenase, potentially affecting the metabolism of vitamin A and indirectly influencing LRAT. | ||||||
9-cis-Retinoic acid | 5300-03-8 | sc-205589 sc-205589B sc-205589C sc-205589D sc-205589A | 1 mg 25 mg 250 mg 500 mg 5 mg | $71.00 $424.00 $3121.00 $5722.00 $148.00 | 10 | |
9-cis-Retinoic acid, a form of vitamin A, may influence retinol metabolism and indirectly modulate LRAT activity. | ||||||