LOXL2 Inhibitors
The chemical class of LOXL2 inhibitors comprises diverse compounds targeting LOXL2 directly or indirectly. PXS-515, a selective LOXL2 inhibitor, directly impedes LOXL2 enzymatic activity, offering a precise tool to investigate LOXL2's role in fibrosis progression. Simtuzumab, an anti-LOXL2 monoclonal antibody, indirectly hinders LOXL2 by preventing substrate access, providing insights into antibody-based therapies for fibrotic disorders. β-Aminopropionitrile (BAPN), an irreversible LOX and LOXL inhibitor, indirectly modulates LOXL2 by disrupting collagen cross-linking, unraveling the consequences of impaired extracellular matrix remodeling. The indirect inhibitors, including CX-4945, Dansylcadaverine, 1,2,4-Triazole, α-Aminoadipic acid, Bisphenol A, Trolox, Galardin, Nordihydroguaiaretic acid (NDGA), and Cilengitide, offer diverse approaches. CX-4945, a protein kinase CK2 inhibitor, indirectly influences LOXL2 by disrupting CK2-mediated phosphorylation events. Dansylcadaverine, a lysyl oxidase inhibitor, impacts LOXL2-dependent collagen cross-linking. 1,2,4-Triazole inhibits lysyl oxidase, altering LOXL2-mediated collagen stabilization. α-Aminoadipic acid, a competitive lysyl oxidase inhibitor, hinders LOXL2-dependent extracellular matrix remodeling. Environmental factors, represented by Bisphenol A, influence LOXL2 by altering signaling pathways associated with LOXL2 expression. Trolox mitigates LOXL2 activation by scavenging reactive oxygen species.
Galardin, a matrix metalloproteinase inhibitor, disrupts proteolytic processing required for LOXL2 function. Nordihydroguaiaretic acid (NDGA), a natural phenolic compound, indirectly influences LOXL2 by modulating oxidative stress and inhibiting lipoxygenase activity. Cilengitide, an integrin inhibitor, impacts LOXL2-mediated collagen cross-linking by disrupting integrin-mediated signaling pathways. Collectively, these inhibitors provide a versatile toolkit for researchers exploring LOXL2's intricate role in tissue homeostasis and diseases associated with aberrant extracellular matrix dynamics.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
3-Aminopropionitrile | 151-18-8 | sc-266473 | 1 g | $104.00 | ||
β-Aminopropionitrile (BAPN), an irreversible LOX and LOXL inhibitor, indirectly modulates LOXL2 by hindering the formation of lysyl oxidase-mediated cross-links in the extracellular matrix. This indirect inhibition disrupts LOXL2-dependent collagen stabilization, influencing tissue architecture. | ||||||
CX-4945 | 1009820-21-6 | sc-364475 sc-364475A | 2 mg 50 mg | $183.00 $800.00 | 9 | |
CX-4945, a protein kinase CK2 inhibitor, indirectly influences LOXL2 by disrupting CK2-mediated phosphorylation events. This indirect inhibition alters the post-translational modification of LOXL2, impacting its stability and function. | ||||||
Dansylcadaverine | 10121-91-2 | sc-214851 sc-214851A sc-214851B | 100 mg 250 mg 1 g | $52.00 $89.00 $240.00 | 4 | |
Dansylcadaverine, a lysyl oxidase inhibitor, indirectly influences LOXL2 by inhibiting the enzymatic activity of lysyl oxidase, a crucial cofactor for LOXL2-mediated collagen cross-linking. This indirect inhibition disrupts LOXL2-dependent extracellular matrix remodeling, providing insights into the consequences of impaired collagen cross-linking in pathological conditions. | ||||||
1,2,4-Triazole | 288-88-0 | sc-253972 sc-253972A | 25 g 100 g | $35.00 $115.00 | ||
1,2,4-Triazole, an antifungal agent, indirectly modulates LOXL2 by inhibiting copper-dependent amine oxidases, including lysyl oxidase, an essential cofactor for LOXL2 activity. This indirect inhibition disrupts LOXL2-mediated collagen cross-linking, influencing tissue remodeling. | ||||||
DL-2-Aminoadipic acid | 542-32-5 | sc-255121 sc-255121A | 1 g 5 g | $70.00 $227.00 | ||
α-Aminoadipic acid, a competitive inhibitor of lysyl oxidase, indirectly influences LOXL2 by hindering lysyl oxidase activity, a crucial cofactor for LOXL2-mediated collagen cross-linking. This indirect inhibition disrupts LOXL2-dependent extracellular matrix remodeling, providing insights into the consequences of impaired lysyl oxidase activity on LOXL2 function. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A, an endocrine-disrupting chemical, indirectly modulates LOXL2 by influencing signaling pathways associated with LOXL2 expression and activation. This indirect inhibition alters the cellular milieu, impacting LOXL2-mediated collagen cross-linking and extracellular matrix remodeling. | ||||||
Trolox | 53188-07-1 | sc-200810 sc-200810A sc-200810B sc-200810C sc-200810D | 500 mg 1 g 5 g 25 g 100 g | $38.00 $67.00 $235.00 $678.00 $1712.00 | 39 | |
Trolox, a water-soluble analog of vitamin E, indirectly influences LOXL2 by scavenging reactive oxygen species (ROS) and preventing oxidative stress. This indirect inhibition mitigates ROS-induced activation of LOXL2, attenuating collagen cross-linking. | ||||||
GM 6001 | 142880-36-2 | sc-203979 sc-203979A | 1 mg 5 mg | $77.00 $270.00 | 55 | |
Galardin (GM 6001), a broad-spectrum matrix metalloproteinase (MMP) inhibitor, indirectly modulates LOXL2 by influencing MMP activity involved in LOXL2 activation. This indirect inhibition disrupts the proteolytic processing required for LOXL2 function, impacting extracellular matrix remodeling. | ||||||
NDGA (Nordihydroguaiaretic acid) | 500-38-9 | sc-200487 sc-200487A sc-200487B | 1 g 5 g 25 g | $109.00 $384.00 $2190.00 | 3 | |
Nordihydroguaiaretic acid (NDGA), a natural phenolic compound, indirectly influences LOXL2 by modulating oxidative stress and inhibiting lipoxygenase activity. This indirect inhibition mitigates LOXL2 activation, attenuating collagen cross-linking and extracellular matrix remodeling. | ||||||
Cilengitide | 188968-51-6 | sc-507335 | 5 mg | $215.00 | ||
Cilengitide, an integrin inhibitor, indirectly modulates LOXL2 by disrupting integrin-mediated signaling pathways associated with LOXL2 activation. This indirect inhibition alters the cellular environment, impacting LOXL2-mediated collagen cross-linking and extracellular matrix remodeling. | ||||||