Date published: 2026-3-7

1-800-457-3801

SCBT Portrait Logo
Seach Input

DL-2-Aminoadipic acid (CAS 542-32-5)

0.0(0)
Write a reviewAsk a question

Alternate Names:
DL-α-Aminoadipic acid
Application:
DL-2-Aminoadipic acid is a glutamine synthetase inhibitor
CAS Number:
542-32-5
Molecular Weight:
161.16
Molecular Formula:
C6H11NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

DL-2-Aminoadipic acid is an excitatory amino acid analogue, which functions as a Gl Syn (glutamine synthetase) inhibitor. Studies indicate that DL-2-Aminoadipic acid is a gliotoxin in low concentrations and displays a low amount of neurotoxicity at longer times of exposure. In addition, DL-2-Aminoadipic acid causes cytotoxicity in N18 neuroblastoma-rat retina hybrid (N18RE105) cells via competitive inhibition of [35S]cystine uptake.


DL-2-Aminoadipic acid (CAS 542-32-5) References

  1. Intrastriatal injection of DL-alpha-aminoadipate reduces kainate toxicity in vitro.  |  McBean, GJ. 1990. Neuroscience. 34: 225-34. PMID: 1970137
  2. Retinal vascular changes after glial disruption in rats.  |  Shen, W., et al. 2010. J Neurosci Res. 88: 1485-99. PMID: 20029988
  3. HIV-Tat elicits microglial glutamate release: role of NAPDH oxidase and the cystine-glutamate antiporter.  |  Gupta, S., et al. 2010. Neurosci Lett. 485: 233-6. PMID: 20849923
  4. Structures and allelopathic effects ofNuphar alkaloids: Nupharolutine and 6,6'-dihydroxythiobinupharidine.  |  Elakovich, SD. and Yang, J. 1996. J Chem Ecol. 22: 2209-19. PMID: 24227298
  5. Prolonged Inner Retinal Photoreception Depends on the Visual Retinoid Cycle.  |  Zhao, X., et al. 2016. J Neurosci. 36: 4209-17. PMID: 27076420
  6. Free amino acids, biogenic amines, and ammonium profiling in tobacco from different geographical origins using microwave-assisted extraction followed by ultra high performance liquid chromatography.  |  Cai, K., et al. 2017. J Sep Sci. 40: 4571-4582. PMID: 29131486
  7. Metabolomic Profiling of Dongxiang Wild Rice Under Salinity Demonstrates the Significant Role of Amino Acids in Rice Salt Stress.  |  Chen, Y., et al. 2021. Front Plant Sci. 12: 729004. PMID: 34630473
  8. Characterization and validation of a chronic retinal neovascularization rabbit model by evaluating the efficacy of anti-angiogenic and anti-inflammatory drugs.  |  Kumar, S., et al. 2022. Int J Ophthalmol. 15: 15-22. PMID: 35047351
  9. Metabolomics analysis reveals four biomarkers associated with the gouty arthritis progression in patients with sequential stages.  |  Lyu, S., et al. 2022. Semin Arthritis Rheum. 55: 152022. PMID: 35584580
  10. Effect of astragaloside IV and salvianolic acid B on antioxidant stress and vascular endothelial protection in the treatment of atherosclerosis based on metabonomics.  |  Kong, XL., et al. 2022. Chin J Nat Med. 20: 601-613. PMID: 36031232
  11. Berberis microphylla G. Forst Intake Reduces the Cardiovascular Disease Plasmatic Markers Associated with a High-Fat Diet in a Mice Model.  |  Olivares-Caro, L., et al. 2023. Antioxidants (Basel). 12: PMID: 36829862
  12. Influence of alkylamides of glutamic acid and related compounds on the central nervous system. II. Syntheses of amides of gutamic acid and related compounds, and their effects on the central nervous system.  |  Kimura, R. and Murata, T. 1971. Chem Pharm Bull (Tokyo). 19: 1301-7. PMID: 5567057
  13. Cystine/glutamate antiporter expression in retinal Müller glial cells: implications for DL-alpha-aminoadipate toxicity.  |  Kato, S., et al. 1993. Neuroscience. 57: 473-82. PMID: 7906874

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

DL-2-Aminoadipic acid, 1 g

sc-255121
1 g
$70.00

DL-2-Aminoadipic acid, 5 g

sc-255121A
5 g
$227.00