LOXL2 Antibody (3C5): sc-293427

LOXL2 Antibody (3C5) is a mouse monoclonal IgG2b kappa light chain antibody that detects LOXL2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-LOXL2 antibody (3C5) is available as a non-conjugated format. The lysyl oxidase (LOX) family of enzymes, which includes LOXL2, plays a crucial role in modifying extracellular matrix components, particularly in forming cross-links in collagen and elastin. This cross-linking maintains structural integrity and elasticity of tissues, vital for proper organ function and tissue repair. LOXL2 localizes to sites of elastogenesis, acting as a cross-linking enzyme, facilitating elastin deposition and interacting with Fibulin-5 to regulate elastin assembly. LOXL2 has been implicated in various cellular processes, including tumor suppression and epithelial-mesenchymal transition, a critical event in cancer progression. LOXL2 interaction with Snail protein can lead to E-cadherin downregulation, promoting invasive characteristics in epithelial cells. Studies have shown that LOXL2 knockdown significantly reduces tumor growth, highlighting LOXL2′s potential as a therapeutic target in cancer treatment.

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LOXL2 Antibody (3C5) References:

1. The LOXL2 gene encodes a new lysyl oxidase-like protein and is expressed at high levels in reproductive tissues.  |  Jourdan-Le Saux, C., et al. 1999. J Biol Chem. 274: 12939-44. PMID: 10212285
2. Lysyl oxidases: a novel multifunctional amine oxidase family.  |  Csiszar, K. 2001. Prog Nucleic Acid Res Mol Biol. 70: 1-32. PMID: 11642359
3. A molecular role for lysyl oxidase in breast cancer invasion.  |  Kirschmann, DA., et al. 2002. Cancer Res. 62: 4478-83. PMID: 12154058
4. Structural and functional diversity of lysyl oxidase and the LOX-like proteins.  |  Molnar, J., et al. 2003. Biochim Biophys Acta. 1647: 220-4. PMID: 12686136
5. Expression of lysyl oxidase isoforms in MC3T3-E1 osteoblastic cells.  |  Atsawasuwan, P., et al. 2005. Biochem Biophys Res Commun. 327: 1042-6. PMID: 15652501
6. Abnormal deposition of collagen around hepatocytes in Wilson's disease is associated with hepatocyte specific expression of lysyl oxidase and lysyl oxidase like protein-2.  |  Vadasz, Z., et al. 2005. J Hepatol. 43: 499-507. PMID: 16023247
7. A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression.  |  Peinado, H., et al. 2005. EMBO J. 24: 3446-58. PMID: 16096638
8. Linking LOXL2 to Cardiac Interstitial Fibrosis.  |  Erasmus, M., et al. 2020. Int J Mol Sci. 21: PMID: 32824630
9. LOXL2 in cancer: regulation, downstream effectors and novel roles.  |  Wen, B., et al. 2020. Biochim Biophys Acta Rev Cancer. 1874: 188435. PMID: 32976981
10. LOXL2 Inhibitors and Breast Cancer Progression.  |  Ferreira, S., et al. 2021. Antioxidants (Basel). 10: PMID: 33669630
11. Multiple Roles of LOXL2 in the Progression of Hepatocellular Carcinoma and Its Potential for Therapeutic Targeting.  |  Radić, J., et al. 2023. Int J Mol Sci. 24: PMID: 37511503
12. LOXL2 inhibition ameliorates pulmonary artery remodeling in pulmonary hypertension.  |  Steppan, J., et al. 2023. bioRxiv.. PMID: 37961202

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LOXL2 Antibody (3C5) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-LOXL2 Antibody (3C5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LOXL2 Antibody (3C5) Specifications

Alternate Product Name: LOXL2

Product Clone Name: 3C5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 675-773

Epitope Target: LOXL2

Epitope Species: human

Product Reactivity/Detection: LOXL2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for LOXL2 Antibody (3C5): N/A