LOC729974 Inhibitors
LOC729974 inhibitors would logically include compounds that inhibit signaling pathways or biological processes directly involved in the activation or function of LOC729974. Considering the typical cellular mechanisms, these inhibitors likely target key nodes within the signaling networks, such as kinases, to exert their inhibitory effects.
The inhibitors listed above would influence LOC729974 through various well-characterized biochemical pathways. For instance, PI3K inhibitors like LY294002 and Wortmannin would inhibit LOC729974 by impeding the PI3K/AKT signaling cascade, which is essential for the activation of many cellular proteins. By blocking PI3K, these compounds would impede the formation of PIP3 and subsequent AKT phosphorylation, indirectly leading to LOC729974 inhibition. Similarly, mTOR inhibitors such as Rapamycin, PP242, AZD8055, and KU-0063794 would inhibit LOC729974 by impeding the mTORC1 and mTORC2 signaling that often regulates cell growth, proliferation, and survival.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Inhibits PI3K by binding to the ATP-binding site, blocking PI3K/AKT signaling. If LOC729974 requires PI3K/AKT for activation or stabilization, LY294002 will inhibit LOC729974 function by impeding this pathway. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Irreversibly inhibits PI3K by covalently binding to its catalytic site, disrupting PI3K/AKT signaling. If LOC729974 is downstream of PI3K/AKT, Wortmannin will inhibit LOC729974 by halting PI3K-mediated activation signals. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Binds FKBP12 and inhibits mTORC1. If LOC729974 activity is mTORC1-dependent, Rapamycin will inhibit LOC729974 by preventing mTORC1-mediated phosphorylation or other regulatory mechanisms. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $56.00 $169.00 | 8 | |
Selective ATP-competitive mTOR inhibitor, affecting both mTORC1 and mTORC2. Inhibition of these complexes by PP242 will decrease LOC729974 activity if it functions downstream of mTOR signaling. | ||||||
MK-2206 dihydrochloride | 1032350-13-2 | sc-364537 sc-364537A | 5 mg 10 mg | $178.00 $325.00 | 67 | |
Allosteric AKT inhibitor, preventing AKT phosphorylation and activation. LOC729974, if an AKT substrate or regulated by AKT signaling, will be inhibited by MK-2206 due to the prevention of necessary AKT-mediated processes. | ||||||
Perifosine | 157716-52-4 | sc-364571 sc-364571A | 5 mg 10 mg | $184.00 $321.00 | 1 | |
Interferes with AKT membrane localization and activation, indirectly inhibiting LOC729974 if AKT signaling is necessary for its function. | ||||||
BEZ235 | 915019-65-7 | sc-364429 | 50 mg | $207.00 | 8 | |
Dual PI3K/mTOR inhibitor, impairing activation of both pathways. LOC729974 will be inhibited by BEZ235 if it is regulated through these kinases. | ||||||
PI-103 | 371935-74-9 | sc-203193 sc-203193A | 1 mg 5 mg | $32.00 $128.00 | 3 | |
Inhibits both PI3K and mTOR, potentially inhibiting LOC729974 by blocking upstream kinase activity required for its function. | ||||||
GDC-0941 | 957054-30-7 | sc-364498 sc-364498A | 5 mg 10 mg | $184.00 $195.00 | 2 | |
Selective inhibitor of PI3K, decreasing PIP3 levels and potentially inhibiting LOC729974 by reducing AKT and downstream signaling. | ||||||
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $160.00 $345.00 | 12 | |
ATP-competitive inhibitor of mTOR, inhibits both mTORC1 and mTORC2. If LOC729974 depends on mTOR signaling, AZD8055 will inhibit its activity. | ||||||