LOC729594 Inhibitors
Staurosporine is a broad-spectrum protein kinase inhibitor with a high degree of potency, disrupting numerous signaling pathways within the cell by halting kinase activity. This interruption can have cascading effects on various proteins that rely on phosphorylation for their activity, including those that may not be directly characterized, such as LOC729594. It is a classic research tool used to understand kinase-dependent cellular mechanisms. LY294002 is another well-known compound that specifically targets the PI3K/Akt pathway, a crucial signaling route for controlling cell survival and proliferation. By blocking this pathway, LY294002 can indirectly affect a multitude of proteins that operate downstream, potentially altering the function of proteins like LOC729594 if they are involved in this pathway.
The MEK inhibitors, U0126 and PD98059, selectively inhibit the MAPK/ERK signaling cascade, a pathway integral to cell division, differentiation, and development. By preventing MEK activity, these inhibitors can modulate the activity of various proteins regulated by the MAPK/ERK pathway, which may include proteins such as LOC729594 whose function or stability is influenced by this pathway. Rapamycin specifically inhibits mTOR, a central protein in a signaling pathway that regulates cell growth and protein synthesis. Its inhibitory action has far-reaching implications for cellular metabolism and can indirectly impact the function of a range of proteins, including LOC729594 if it is connected to the mTOR signaling network. SB203580 and SP600125 target the stress-activated MAP kinases p38 and JNK, respectively. These kinases are involved in the cellular response to cytokines and stress, and their inhibition can alter the activity of a suite of proteins involved in inflammatory responses and apoptosis. Wortmannin, a potent inhibitor of phosphoinositide 3-kinases, disrupts PI3K/Akt signaling, which is pivotal for many cellular functions, including growth, proliferation, and survival. Such disruption can have a broad impact on proteins that are part of or regulated by the PI3K/Akt pathway.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine disrupts cellular signaling by inhibiting protein kinases, which can lead to altered activity of proteins regulated by these kinases, including potentially LOC729594. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 interferes with the PI3K/Akt pathway, impacting cell survival and proliferation, thus affecting downstream proteins, which may include LOC729594 if it is part of this pathway. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 inhibits MEK in the MAPK/ERK pathway, which could influence the activity of proteins regulated by this pathway, including potentially LOC729594. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin targets mTOR signaling, affecting cell growth and protein synthesis, which can alter the function of proteins regulated by this pathway, potentially including LOC729594. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 inhibits p38 MAP kinase, affecting proteins modulated by this pathway, which can include LOC729594 if it is involved in p38 MAPK-regulated processes. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of MEK, affecting the MAPK/ERK signaling pathway and potentially influencing LOC729594 if it is regulated by this pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits JNK, which can alter apoptosis and other cellular processes, thereby influencing the activity of proteins involved in these processes, potentially including LOC729594. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin, a phosphoinositide 3-kinase inhibitor, disrupts the PI3K/Akt pathway, potentially affecting proteins downstream, which may include LOC729594. | ||||||
QNZ | 545380-34-5 | sc-200675 | 1 mg | $115.00 | 12 | |
This inhibitor prevents NF-κB activation, which can affect transcription of genes and the activity of proteins regulated by NF-κB-dependent signaling, potentially including LOC729594. | ||||||
2-Methoxyestradiol | 362-07-2 | sc-201371 sc-201371A | 10 mg 50 mg | $70.00 $282.00 | 6 | |
2-Methoxyestradiol inhibits HIF-1α and microtubule polymerization, potentially affecting proteins involved in angiogenesis and cellular division, which may include LOC729594. | ||||||