LOC729174 Inhibitors
Wortmannin and LY294002 operate as phosphoinositide 3-kinase (PI3K) inhibitors, directly impeding the PI3K/Akt pathway, an intersection potentially critical to LOC729174's regulation or expression. Staurosporine emerges as a broad-spectrum kinase inhibitor, altering phosphorylation-dependent signaling and thus, the activity and stability of LOC729174. Further, the MAPK/ERK pathway, integral to cellular response and gene expression, is targeted by U0126 and PD98059, which selectively inhibit MEK1/2, potentially suppressing LOC729174's involvement in these pathways. SB203580 and SP600125 each lend specificity to inhibition, the former curtailing p38 MAP kinase thus impacting stress and cytokine signaling, and the latter constraining JNK to modulate pathways related to inflammation and apoptosis where LOC729174 may play a part.
Src family kinases, implicated in a host of cellular functions including differentiation and proliferation, are targeted by PP2, which could influence LOC729174 activity. Ibrutinib, on the other hand, specifically inhibits Bruton's tyrosine kinase (BTK), perturbing B cell receptor signaling and potentially altering signaling cascades that engage LOC729174. Bortezomib stands out as a proteasome inhibitor, skewing the protein turnover balance and potentially elevating the levels of LOC729174 within the cell, thus modifying its functional impact. Rapamycin and AZD8055, as inhibitors of the mammalian target of rapamycin (mTOR), disrupt mTORC1 and mTORC2 signaling complexes, which are pivotal in cell growth and metabolism, likely intersecting with the biological processes regulated by LOC729174.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a steroidal metabolite that serves as a potent and irreversible inhibitor of phosphoinositide 3-kinases (PI3K), which can disrupt downstream signaling pathways that LOC729174 may operate within, leading to altered protein function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a synthetic molecule that, like Wortmannin, inhibits PI3K. It blocks the ATP binding site of PI3K, leading to the suppression of the PI3K/Akt pathway, which may intersect with LOC729174's function or expression. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor that can interfere with a multitude of kinases, likely affecting phosphorylation patterns that control LOC729174's activity or stability. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of MEK1/2, enzymes involved in the MAPK/ERK pathway. By inhibiting MEK, U0126 can suppress the activation of ERK, potentially influencing LOC729174's role in cell signaling. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 specifically inhibits p38 MAP kinase, impacting stress response pathways and cytokine production, which may modulate the function or expression of LOC729174. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an anthrapyrazolone inhibitor of JNK, altering signaling pathways related to inflammation and apoptosis that could intersect with LOC729174's regulatory mechanisms. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an inhibitor of Src family tyrosine kinases, which can modulate various cellular processes including differentiation, possibly affecting LOC729174's activity through these pathways. | ||||||
Ibrutinib | 936563-96-1 | sc-483194 | 10 mg | $153.00 | 5 | |
Ibrutinib is a selective and irreversible inhibitor of Bruton's tyrosine kinase (BTK), influencing B cell receptor signaling, which may alter signaling cascades involving LOC729174. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor, leading to the accumulation of proteins marked for degradation. This can affect numerous cellular processes including the stability of proteins like LOC729174. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor that works by preventing the activation of MEK1/2, thereby blocking the MAPK/ERK pathway, which may play a role in the regulation of LOC729174. | ||||||