LOC727847 Inhibitors
LOC727847 inhibitors are a class of chemical compounds hypothesized to indirectly inhibit the functional activity of the protein LOC727847. These inhibitors do not directly target LOC727847 but act on various signaling pathways and cellular processes that are potentially relevant to the regulation and activity of LOC727847. For instance, staurosporine and LY294002 are kinase inhibitors that may impede phosphorylation events vital for LOC727847 function or activation.
For instance, staurosporine and LY294002 are kinase inhibitors that may impede phosphorylation events vital for LOC727847 function or activation. Rapamycin, a specific mTOR pathway inhibitor, and cyclosporin A, a calcineurin inhibitor, could prevent LOC727847 activity by inhibiting downstream signaling required for its function
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent kinase inhibitor that can inhibit a broad range of protein kinases. If LOC727847 is a kinase or is regulated by phosphorylation, staurosporine can lead to its functional inhibition by preventing its phosphorylation or the phosphorylation of proteins that regulate LOC727847. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor that would inhibit the mTOR pathway. If LOC727847 function is mTOR-dependent, rapamycin could lead to its inactivation by preventing mTOR-mediated signaling events that are required for LOC727847's activity. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
An immunosuppressant that inhibits calcineurin. If LOC727847's activity is regulated by dephosphorylation events mediated by calcineurin, cyclosporin A's inhibition of calcineurin could result in decreased activity of LOC727847. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that prevents the activation of the PI3K/AKT pathway. If LOC727847 is activated downstream of PI3K, inhibition of PI3K by LY294002 could lead to a decrease in LOC727847 activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
A MEK inhibitor that blocks the MAPK/ERK pathway. If LOC727847 is a downstream target of ERK or is regulated by the MAPK/ERK pathway, PD98059 could lead to reduced activity of LOC727847 by preventing the necessary phosphorylation events. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A p38 MAPK inhibitor that could inhibit the activity of LOC727847 if it is regulated by stress-activated p38 MAPK signaling. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of JNK, which is involved in the cellular stress response. If LOC727847 is regulated by JNK signaling, SP600125 would prevent activation of this pathway and thus decrease LOC727847 activity. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor that could affect the degradation of regulatory proteins that control LOC727847 activity. If LOC727847 is stabilized by proteins that are degraded by the proteasome, bortezomib could indirectly decrease LOC727847 activity by stabilizing its inhibitors. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
Similar to bortezomib, it is a proteasome inhibitor that could lead to an accumulation of proteins that negatively regulate LOC727847, thereby reducing its activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A PI3K inhibitor like LY294002, wortmannin could lead to the functional inhibition of LOC727847 by blocking the PI3K/AKT pathway, assuming LOC727847's activity is downstream of this signaling route. | ||||||