Date published: 2025-12-24

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LOC646012 Inhibitors

The designation LOC646012 Inhibitors represents a specialized class of chemical compounds specifically designed to modulate the activity of LOC646012, a molecular target currently undergoing scientific investigation. These inhibitors are intricately formulated through principles grounded in medicinal chemistry, with a primary emphasis on selectively interfering with the normal functions of LOC646012 within cellular processes. The structural features of LOC646012 Inhibitors undergo a meticulous optimization process, often incorporating computational modeling and structure-activity relationship studies, to ensure their molecular configurations are precisely tuned for effective binding to the target.

The significance of LOC646012 Inhibitors lies in their potential to disrupt the biochemical activities associated with LOC646012, a molecular entity believed to play a role in various biological pathways. Researchers in this field delve into the three-dimensional structure of LOC646012 and its binding interactions with inhibitors, aiming to unravel the intricate molecular mechanisms underlying inhibition. The study of LOC646012 Inhibitors contributes to a broader understanding of cellular processes, offering insights into the roles played by LOC646012 in diverse biological pathways and expanding our knowledge of the regulatory networks governing cellular activities. This research not only advances our comprehension of the molecular intricacies surrounding LOC646012 but also contributes to the broader scientific understanding of molecular targets and their involvement in fundamental cellular functions.

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

MLN 8054

869363-13-3sc-484828
5 mg
$398.00
(0)

By inhibiting HDM2, these compounds prevent p53 degradation, potentially modulating its cellular levels and activity.

Mithramycin A

18378-89-7sc-200909
1 mg
$54.00
6
(1)

These inhibitors can prevent acetylation of p53, which is necessary for its activation, thus indirectly influencing p53 expression and activity.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

ATM kinase is involved in DNA damage response and can phosphorylate p53. Inhibition of ATM could therefore affect p53 stabilization and activity.

BML-277

516480-79-8sc-200700
sc-200700A
10 mg
50 mg
$129.00
$482.00
2
(1)

Chk2 also phosphorylates p53 in response to DNA damage; its inhibition can alter p53 activity and possibly its expression.

Nutlin-3

548472-68-0sc-45061
sc-45061A
sc-45061B
1 mg
5 mg
25 mg
$56.00
$212.00
$764.00
24
(1)

Although Nutlin-3 stabilizes p53 by inhibiting its interaction with MDM2, it can be used to study the dynamics of p53 expression and turnover.

Tenovin-6

1011557-82-6sc-224296
sc-224296A
1 mg
5 mg
$272.00
$1214.00
9
(1)

Tenovin-6 inhibits Sirt1 and Sirt2, leading to increased acetylation and activation of p53, which might affect its expression indirectly.

Pifithrin-α hydrobromide

63208-82-2sc-45050
sc-45050A
5 mg
25 mg
$118.00
$287.00
36
(1)

Pifithrin-α(HBr) inhibits the transcriptional activity of p53, potentially leading to downregulated expression of its target genes.

RG-7112

939981-39-2sc-507292
10 mg
$520.00
(0)

RG7112 mimics p53 and binds to MDM2, which may stabilize p53 and alter its expression levels.

Panobinostat

404950-80-7sc-208148
10 mg
$196.00
9
(1)

Inhibition of histone deacetylases can affect p53 acetylation and its interaction with other transcriptional regulators, modifying its expression.