LOC100130933 Activators
Chemical activators of LOC100130933 can facilitate its activation through several biochemical pathways. Phorbol 12-myristate 13-acetate (PMA) and TPA, both of which are different names for the same compound, directly activate protein kinase C (PKC). The activation of PKC is a crucial step as it can lead to the phosphorylation of downstream proteins, including LOC100130933, resulting in its activation. Forskolin, by elevating cAMP levels, activates protein kinase A (PKA), which is known to phosphorylate a wide array of proteins within the same signaling pathway as LOC100130933, thereby activating it. Another chemical, Ionomycin, increases intracellular calcium levels, which can activate calcium-dependent protein kinases that are capable of phosphorylating and activating proteins like LOC100130933.
In a similar vein, compounds such as Oligomycin and Calyculin A exert their effects by disrupting cellular homeostasis. Oligomycin inhibits the mitochondrial ATP synthase, leading to activation of AMP-activated protein kinase (AMPK), which may directly phosphorylate LOC100130933. Calyculin A, as well as Okadaic Acid, inhibits protein phosphatases 1 and 2A, causing an increase in the phosphorylation state of proteins, which can lead to the activation of LOC100130933. Thapsigargin, by inhibiting the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), disrupts calcium homeostasis and potentially activates kinases that could phosphorylate LOC100130933. Anisomycin activates stress-activated protein kinases such as JNK, which could directly phosphorylate LOC100130933, leading to its activation. Staurosporine, at low concentrations, can activate PKC, thus phosphorylating and activating downstream proteins including LOC100130933. Bryostatin 1 interacts with PKC, potentially causing the phosphorylation and activation of LOC100130933. The collective action of these chemicals on various kinases and phosphatases underscores the complex regulation of protein activation and the intricate web of signaling pathways that converge on proteins like LOC100130933.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA directly activates protein kinase C (PKC), and PKC activation leads to the phosphorylation and activation of downstream proteins, potentially including LOC100130933. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin raises intracellular Ca2+ levels, which can activate calcium-dependent protein kinases that directly phosphorylate and activate proteins, potentially including LOC100130933. | ||||||
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $179.00 $612.00 $1203.00 $5202.00 $9364.00 | 26 | |
Oligomycin inhibits mitochondrial ATP synthase, leading to cellular stress and the activation of AMPK which may directly phosphorylate and activate downstream proteins like LOC100130933. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A inhibits protein phosphatases 1 and 2A, which can result in the increased phosphorylation and activation of downstream proteins, potentially including LOC100130933. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid inhibits protein phosphatases PP1 and PP2A, leading to increased phosphorylation and potential direct activation of proteins in the same pathway as LOC100130933. | ||||||
Phorbol | 17673-25-5 | sc-253267 | 5 mg | $270.00 | 1 | |
Phorbol esters activate PKC, which can phosphorylate a suite of proteins, potentially leading to the direct activation of LOC100130933 through phosphorylation. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin disrupts calcium homeostasis by inhibiting the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), potentially leading to the activation of kinases that phosphorylate and activate LOC100130933. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin activates stress-activated protein kinases like JNK, which could lead to the direct phosphorylation and activation of proteins in the same signaling cascade as LOC100130933. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent PKC inhibitor but at low concentrations, it can paradoxically activate PKC, leading to the phosphorylation and direct activation of downstream proteins such as LOC100130933. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $245.00 | 9 | |
Bryostatin 1 binds to and modulates PKC, potentially leading to the phosphorylation and direct activation of downstream proteins, which may include LOC100130933. | ||||||