LOC100041366 Inhibitors
LOC100041366 inhibitors inhibition of DNA transcription by chemicals like Actinomycin D can lead to a broad decrease in gene expression, including that of LOC100041366. By binding to DNA, Actinomycin D prevents RNA polymerase from transcribing DNA into mRNA, thus affecting the expression of a multitude of genes. On the level of protein translation, compounds like Cycloheximide exert their effects by binding to the ribosomal units responsible for synthesizing proteins. This binding inhibits the elongation step in protein synthesis, leading to a decrease in the production of proteins throughout the cell.
In the realm of protein degradation, proteasome inhibitors such as Bortezomib and MG-132 interfere with the proteasome's ability to degrade unwanted or misfolded proteins. This inhibition can result in the accumulation of a wide array of cellular proteins and may affect the stability or turnover of proteins like LOC100041366. Signaling pathway modulators like Rapamycin and LY294002 disrupt processes downstream of receptors, such as the mTOR and PI3K pathways, respectively.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Interacts with DNA and inhibits RNA polymerase, thus blocking transcription. This can reduce expression of many genes, possibly including LOC100041366. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Binds to the E-site of the 60S ribosomal subunit, inhibiting translational elongation and thus protein synthesis in eukaryotic organisms. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Proteasome inhibitor that prevents the degradation of ubiquitinated proteins, potentially affecting protein levels, including LOC100041366 if it is regulated by proteasomal degradation. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
Reversible proteasome inhibitor that can lead to accumulation of proteins within the cell, potentially affecting the function or stability of LOC100041366. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Binds to FKBP12 and inhibits the mTOR pathway, which is involved in cell growth and protein synthesis, potentially influencing LOC100041366 levels or activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A specific inhibitor of phosphoinositide 3-kinases (PI3K), which can alter signaling pathways involved in cell survival and protein synthesis. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
Inhibits p38 MAP kinase, affecting inflammatory response and possibly the phosphorylation state of various proteins, including potential targets such as LOC100041366. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
Specific inhibitor of MEK, which blocks the activation of MAPK/ERK, potentially altering signaling pathways that influence numerous proteins. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A potent inhibitor of phosphoinositide 3-kinases (PI3K), which can affect a broad range of cellular processes including those potentially regulating LOC100041366. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
Inhibits JNK, which may affect apoptosis and other cellular processes, possibly influencing the function or regulation of various proteins. | ||||||