LMP7 Activators
LMP7, a critical component of the immunoproteasome, assumes a pivotal role in the intricate process of antigen presentation and regulation of immune responses. The identified compounds, including Betulinic Acid, N-acetyl-L-cysteine (NAC), Honokiol, Carnosic Acid, Withaferin A, Curcumin, Resveratrol, Celastrol, Oleanolic Acid, Lycopene, Thymoquinone, and Ursolic Acid, have been recognized for their importance as activators of LMP7. These compounds, sourced from natural origins, demonstrate the capacity to modulate cellular pathways associated with proteasome regulation, thereby facilitating the activation of LMP7. While the precise mechanisms underlying these effects are yet to be fully elucidated, the compounds are believed to exert their influence on cellular redox status, signaling cascades, and other pathways. This indirect enhancement of LMP7 activity within the immunoproteasome suggests a multifaceted impact on the cellular machinery.
The modulation of LMP7 by these compounds provides valuable insights into the realm of immune response modulation and antigen processing. Understanding the intricate interplay between these compounds and LMP7 opens up possibilities for developing targeted strategies to harness the immunoproteasome's regulatory functions. Further research is warranted to unravel the precise molecular interactions of these LMP7 activators. Investigating their effects on immune cells, antigen-presenting cells, and overall immune system dynamics will contribute to a comprehensive understanding of their applications. The exploration of these natural compounds as LMP7 activators not only expands our knowledge of immunoproteasome regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Betulinic Acid is a natural compound that has been suggested to activate LMP7. While the exact mechanism is not fully elucidated, it is proposed to modulate cellular pathways, potentially impacting the expression or activity of LMP7 and promoting its activation. Betulinic Acid's influence on cellular processes may indirectly lead to the activation of LMP7 and affect its proteasomal functions. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
N-acetyl-L-cysteine (NAC) is a thiol-containing compound that may indirectly activate LMP7. By replenishing cellular glutathione levels, NAC can influence redox signaling and impact pathways involved in proteasome regulation, potentially leading to the activation of LMP7. The modulation of cellular redox status by NAC might contribute to the activation of LMP7, influencing its proteolytic functions within the proteasome. | ||||||
Honokiol | 35354-74-6 | sc-202653 sc-202653A | 10 mg 25 mg | $118.00 $178.00 | 4 | |
Honokiol, a natural compound, has been suggested to activate LMP7. Although the precise mechanism is not fully understood, Honokiol is proposed to modulate signaling pathways related to proteasome regulation, potentially leading to the activation of LMP7. Its impact on cellular processes may indirectly promote the activation of LMP7 and influence its proteasomal functions. | ||||||
Carnosic acid | 3650-09-7 | sc-202520 sc-202520A | 10 mg 50 mg | $75.00 $221.00 | 6 | |
Carnosic Acid, a natural compound, is proposed to activate LMP7. While the exact mechanism is not fully elucidated, Carnosic Acid is suggested to modulate cellular pathways related to proteasome regulation, potentially leading to the activation of LMP7. Its influence on cellular processes may indirectly promote the activation of LMP7 and impact its proteasomal functions. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Withaferin A is a natural compound that may activate LMP7. Although the precise mechanism is not fully understood, Withaferin A is suggested to modulate signaling pathways related to proteasome regulation, potentially leading to the activation of LMP7. Its impact on cellular processes may indirectly promote the activation of LMP7 and influence its proteasomal functions within the cell. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a natural compound, has been suggested to activate LMP7. While the exact mechanism is not fully elucidated, Curcumin is proposed to modulate cellular pathways related to proteasome regulation, potentially leading to the activation of LMP7. Its influence on cellular processes may indirectly promote the activation of LMP7 and impact its proteasomal functions. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a natural compound, has been suggested to activate LMP7. Although the precise mechanism is not fully understood, Resveratrol is proposed to modulate cellular pathways related to proteasome regulation, potentially leading to the activation of LMP7. Its impact on cellular processes may indirectly promote the activation of LMP7 and influence its proteasomal functions. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
Celastrol is a natural compound that may activate LMP7. Although the exact mechanism is not fully understood, Celastrol is suggested to modulate signaling pathways related to proteasome regulation, potentially leading to the activation of LMP7. Its influence on cellular processes may indirectly promote the activation of LMP7 and impact its proteasomal functions within the cell. | ||||||
Oleanolic Acid | 508-02-1 | sc-205775 sc-205775A | 100 mg 500 mg | $86.00 $302.00 | 8 | |
Oleanolic Acid, a natural compound, has been suggested to activate LMP7. While the exact mechanism is not fully elucidated, Oleanolic Acid is proposed to modulate cellular pathways related to proteasome regulation, potentially leading to the activation of LMP7. Its influence on cellular processes may indirectly promote the activation of LMP7 and impact its proteasomal functions. | ||||||
Lycopene | 502-65-8 | sc-205738 sc-205738A sc-205738B | 1 mg 5 mg 1 g | $146.00 $582.00 $6248.00 | 4 | |
Lycopene, a natural compound, has been suggested to activate LMP7. Although the precise mechanism is not fully understood, Lycopene is proposed to modulate cellular pathways related to proteasome regulation, potentially leading to the activation of LMP7. Its influence on cellular processes may indirectly promote the activation of LMP7 and impact its proteasomal functions. | ||||||