Lmf2 Activators
Lipase maturation factor 2 (LMF2) is a protein encoded by the LMF2 gene in humans. It plays a crucial role in the proper folding and maturation of lipoprotein lipase (LPL) and hepatic lipase (HL), which are enzymes essential for the metabolism of lipoproteins. LPL is responsible for the hydrolysis of triglycerides in lipoproteins, such as chylomicrons and very-low-density lipoproteins (VLDL), into free fatty acids, which can be taken up by tissues and used for energy production or storage. Similarly, HL facilitates the clearance of triglycerides from intermediate-density lipoproteins (IDL) and high-density lipoproteins (HDL).
LMF2 is located in the endoplasmic reticulum (ER) membrane, where it assists in the post-translational modification of LPL and HL. It is believed to function as part of a larger complex that is necessary for the correct folding of these lipases, which is a prerequisite for their activity. Mutations in the LMF2 gene can lead to a deficiency in functional LPL and HL, resulting in disorders of lipid metabolism such as combined lipase deficiency (CLD). While the exact mechanisms by which LMF2 facilitates the maturation of lipases are not completely understood, it is evident that LMF2 is indispensable for the proper processing and ultimate enzymatic activity of LPL and HL within lipid metabolism.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $41.00 | 9 | |
A lipid-regulating drug that activates peroxisome proliferator-activated receptor alpha (PPARα), potentially influencing lipid metabolism pathways involving LMF2. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
A PPARγ agonist, used to treat insulin resistance and diabetes, could indirectly affect LMF2 activity in lipid metabolism. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $62.00 $124.00 | 1 | |
Influences lipid metabolism, potentially impacting pathways related to LMF2 function. | ||||||
Lipase Inhibitor, THL | 96829-58-2 | sc-203108 | 50 mg | $52.00 | 7 | |
An inhibitor of gastrointestinal lipases, might have indirect effects on LMF2 via altered lipid digestion and absorption. | ||||||
Ezetimibe | 163222-33-1 | sc-205690 sc-205690A | 25 mg 100 mg | $96.00 $241.00 | 12 | |
Lowers cholesterol absorption, potentially affecting lipid metabolism pathways relevant to LMF2. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $31.00 $89.00 $135.00 $443.00 | 13 | |
A statin that lowers cholesterol, could influence lipid metabolism pathways involving LMF2. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Has been shown to modulate lipid metabolism, potentially impacting LMF2 function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Modulates various cellular pathways, including those in lipid metabolism, potentially affecting LMF2. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Influences lipolysis, potentially impacting lipid metabolism pathways related to LMF2. | ||||||