LIN-39 Inhibitors
Chemical inhibitors of the protein LIN-39 act through diverse mechanisms to modulate its function. Palbociclib, a CDK4/6 inhibitor, can impede the cell cycle progression, which is crucial for the proper function of LIN-39 in cell division. Similarly, by inhibiting the TGF-β receptor, SB-431542 can reduce signaling pathways that influence the expression and activity of LIN-39. The PI3K/Akt signaling pathway, which can be disrupted by LY294002, is often upstream of several developmental genes, including LIN-39, and its inhibition can reduce the signals required for LIN-39's role in development. U0126 operates by inhibiting MEK1/2, diminishing the MAPK/ERK pathway's regulation of LIN-39 expression and activity. XAV-939 and LGK-974 target the Wnt signaling pathway, with XAV-939 stabilizing axin leading to β-catenin degradation, and LGK-974 inhibiting the secretion and activity of Wnt proteins, both of which can limit the activity of LIN-39 in developmental processes.
Further, PF-562271, a focal adhesion kinase inhibitor, can impede processes such as cell migration and proliferation where LIN-39's function is crucial. DAPT, by inhibiting gamma-secretase, can affect Notch signaling that interacts with the regulation of LIN-39, impacting its role in lineage specification. LDN-193189, a BMP inhibitor, and SP600125, a JNK inhibitor, can alter the transcriptional regulation environment of LIN-39, affecting its function in organ development and cell differentiation. AZD8055, which inhibits both mTORC1 and mTORC2, can impact cell growth and proliferation, thereby modulating the developmental contexts in which LIN-39 operates. Lastly, Y-27632, a ROCK inhibitor, can modulate cytoskeleton dynamics and cell adhesion, processes in which LIN-39 is involved, thus affecting its role in cell patterning and development.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $321.00 | ||
Palbociclib is a CDK4/6 inhibitor which inhibits the cell cycle progression. Since LIN-39 is involved in developmental processes and is a part of the Hox gene family that can regulate cell proliferation, inhibition of CDK4/6 can lead to reduced cell division where LIN-39 might be playing a role. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB-431542 is an inhibitor of the TGF-β receptor. TGF-β signaling can influence the expression of Hox genes, and LIN-39 is a member of this family. By inhibiting TGF-β signaling, SB-431542 could reduce the cellular context that allows LIN-39 to function properly. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor which can disrupt the PI3K/Akt signaling pathway. This pathway is often upstream of several developmental genes, including those in the Hox gene family, to which LIN-39 belongs. Inhibiting PI3K could reduce the signaling required for LIN-39's role in developmental processes. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is an inhibitor of MEK1/2, key kinases in the MAPK/ERK pathway. The MAPK/ERK pathway can regulate Hox gene expression and activity, thus inhibiting it with U0126 could diminish the necessary signals LIN-39 relies on for its function in development. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $36.00 $117.00 $525.00 | 26 | |
XAV-939 inhibits Wnt signaling by stabilizing axin, which leads to β-catenin degradation. Since Wnt signaling can regulate the expression of Hox genes and LIN-39 is part of that family, inhibiting Wnt signaling with XAV-939 could reduce LIN-39's functional role. | ||||||
Wnt-C59 | 1243243-89-1 | sc-475634 sc-475634A sc-475634B | 5 mg 10 mg 50 mg | $214.00 $326.00 $1275.00 | 1 | |
LGK-974 is a porcupine inhibitor that prevents the secretion and activity of Wnt proteins. By inhibiting Wnt signaling, LGK-974 could limit the activity of LIN-39 by disrupting the signaling pathways that regulate developmental processes LIN-39 is associated with. | ||||||
PF-562271 | 717907-75-0 | sc-478488 sc-478488A sc-478488B | 5 mg 10 mg 50 mg | $312.00 $474.00 $1124.00 | 3 | |
PF-562271 is a focal adhesion kinase (FAK) inhibitor. FAK signaling is important for cell migration and proliferation, processes where Hox genes like LIN-39 might be involved. Inhibiting FAK could therefore indirectly inhibit LIN-39 function in these processes. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $40.00 $120.00 $480.00 $2141.00 | 47 | |
DAPT is a gamma-secretase inhibitor which can inhibit Notch signaling. Since Notch signaling can interact with Hox genes regulation, and LIN-39 is a Hox gene, inhibiting Notch could impair LIN-39's role in lineage specification and development. | ||||||
4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline | 1062368-24-4 | sc-476297 | 5 mg | $240.00 | ||
LDN-193189 is a BMP inhibitor which impedes BMP signaling. BMP signaling can influence Hox gene expression; by inhibiting this pathway, LDN-193189 might diminish the regulatory environment LIN-39 requires for its function in patterning and development. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor. The JNK pathway can affect transcriptional regulation of developmental genes, including LIN-39. Inhibition of JNK may reduce the activity of LIN-39 in processes such as organ development and cell differentiation. | ||||||