LIME Activators
LIME (Lck Interacting Molecule) is an integral transmembrane adapter protein, primarily functioning within the realm of immune cell signaling, specifically in T cells. This protein, which is encoded by the LIME1 gene, contributes significantly to T cell receptor (TCR) signaling pathways. Upon T cell activation, LIME becomes expressed, associating with the protein tyrosine kinase Lck to aid in the propagation of TCR signaling. LIME's role in modulating T cell activation and response underscores its critical function within the immune system, influencing how it reacts to a variety of stimuli.
The capacity of various chemicals to induce LIME expression forms an area of interest. Retinoic Acid, a known regulator of cell differentiation, might stimulate LIME expression during T cell differentiation. Likewise, Dexamethasone, recognized for its role in modulating immune responses, could increase LIME expression by enhancing T cell activation and response. Phorbol 12-myristate 13-acetate (PMA), an activator of Protein Kinase C, might induce LIME expression by instigating the PKC pathway, integral to T cell activation. Other compounds like Cyclosporine A, Rapamycin, and Staurosporine, renowned for inhibiting various cellular pathways, could boost LIME expression by altering these pathways, thus indirectly affecting LIME expression. Additionally, compounds with anti-inflammatory effects like Curcumin, Salicylic Acid, Epigallocatechin Gallate (EGCG), Capsaicin, and Quercetin might enhance LIME expression by intensifying immune responses. Resveratrol, a known stimulant of SIRT1, might foster LIME expression by activating SIRT1, which manages cellular stress responses and could indirectly enhance LIME expression.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid, a potent regulator of cell differentiation and proliferation, could potentially stimulate LIME expression during T cell differentiation, a stage at which LIME's role is critical. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone, a glucocorticoid known to modulate immune response, could potentially escalate LIME expression by enhancing the activation and response of T cells, a process intrinsically linked with LIME. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA, an activator of Protein Kinase C, might trigger LIME expression by stimulating the PKC pathway, a key player in T cell activation where LIME is typically expressed. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine, a broad-spectrum protein kinase inhibitor, may encourage LIME expression by inhibiting kinases involved in T cell activation, a condition that might favor increased LIME expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, renowned for its immune-modulating effects, could potentially foster LIME expression by amplifying immune responses, possibly leading to an increase in T cell activation and subsequent LIME production. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a known activator of SIRT1, might promote LIME expression by stimulating SIRT1, a protein involved in managing cellular stress responses, which could indirectly favor LIME expression. | ||||||
Salicylic acid | 69-72-7 | sc-203374 sc-203374A sc-203374B | 100 g 500 g 1 kg | $47.00 $94.00 $119.00 | 3 | |
Salicylic Acid, noted for its anti-inflammatory effects, may potentially enhance LIME expression by modulating immune responses, which might lead to a condition favoring increased LIME expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
(-)-Epigallocatechin Gallate, a type of catechin with anti-inflammatory effects, might galvanize LIME expression by amplifying immune responses, possibly leading to an increase in T cell activation and subsequent LIME production. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin, a compound affecting pain perception and inflammation, could potentially spur LIME expression by modulating immune responses, possibly leading to a condition enhancing LIME production. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid with anti-inflammatory properties, might potentially kindle LIME expression by intensifying immune responses, which could lead to an environment conducive to increased LIME expression. | ||||||