LENG8 Inhibitors
LENG8 inhibitors are a class of chemicals that influence various biochemical and cellular pathways, ultimately leading to the indirect inhibition of LENG8, a protein implicated in the assembly of protein complexes. The mechanisms of these inhibitors are diverse, targeting different aspects of cellular function that are upstream or intertwined with LENG8's activity within the cell. For instance, mTOR inhibitors like rapamycin work by suppressing overall protein synthesis, which in turn would reduce the substrate availability for the assembly of protein complexes, indirectly affecting LENG8 activity. Similarly, PI3K inhibitors such as wortmannin and LY294002 disrupt the PI3K/AKT/mTOR signaling cascade, leading to a decrease in protein synthesis and complex assembly, potentially inhibiting LENG8.
Other inhibitors target various cellular stress and survival pathways that may intersect with LENG8's role in the cell. For example, PD98059 and SP600125 inhibit the MAPK/ERK and JNK pathways, respectively, which could indirectly reduce LENG8 activity if it is tied to the signaling events downstream of these pathways. SB203580's inhibition of p38 MAPK would affect inflammatory response and differentiation, potentially inhibiting LENG8 if it plays a role in these processes. Inhibitors like 2-Deoxy-D-glucose and 3-Methyladenine alter cellular energy metabolism and autophagy processes, respectively. By disrupting these pathways, they could indirectly influence LENG8's function related to energy-dependent processes or protein turnover.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
mTOR inhibitor that downregulates protein synthesis pathways. Since LENG8 is associated with protein complex assembly, rapamycin-induced mTOR inhibition would reduce the availability of proteins for complex assembly, indirectly inhibiting LENG8 function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
PI3K inhibitor that interrupts the PI3K/AKT/mTOR signaling pathway. LENG8 is implicated in protein complex assembly that could be downstream of mTOR signaling; thus, wortmannin can indirectly inhibit LENG8 by reducing protein synthesis and complex assembly. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
AKT inhibitor that prevents the activation of downstream proteins involved in cell survival and growth. If LENG8 function is tied to these cellular processes, triciribine's inhibition of AKT would indirectly inhibit LENG8 by disrupting these processes. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Another PI3K inhibitor with a similar mechanism to wortmannin, LY294002 would lead to the indirect inhibition of LENG8 by disrupting PI3K/AKT/mTOR pathway and associated protein complex assembly. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Inhibitor of ADP-ribosylation factor (ARF), which disrupts Golgi apparatus function and vesicular trafficking. As LENG8 is implicated in complex assembly, disruption of vesicular trafficking could indirectly inhibit LENG8 function by altering protein processing and transport. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
MEK inhibitor that blocks the MAPK/ERK pathway. If LENG8 function is associated with signaling events downstream of ERK, PD98059 would result in indirect inhibition of LENG8 by blocking these signaling events. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK inhibitor that blocks JNK signaling, which is involved in stress responses, apoptosis, and other cellular processes. If LENG8 has a role in these pathways, inhibition of JNK could indirectly affect LENG8 function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
p38 MAPK inhibitor affecting inflammatory responses and differentiation pathways. If LENG8 is involved in these pathways, then SB203580 would indirectly inhibit LENG8 by dampening the pathway's activity. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
Glycolysis inhibitor that affects energy metabolism. If LENG8 function is connected to cellular energy status, inhibition of glycolysis would interfere with the energy-dependent processes in which LENG8 might be involved. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Lysosomal inhibitor that affects autophagy and endosomal trafficking. By altering the autophagic process, chloroquine could indirectly inhibit LENG8 if it is involved in lysosomal function or protein degradation pathways. | ||||||