Date published: 2025-11-1

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LDLRAD2 Activators

LDLRAD2 activators belong to a chemical class of compounds designed to interact with and modulate the activity of the LDLRAD2 protein. LDLRAD2, also known as Low-Density Lipoprotein Receptor Class A Domain-Containing Protein 2, is a relatively newly identified protein that is a member of the low-density lipoprotein receptor (LDLR) family. While the exact functions of LDLRAD2 are still under investigation, it is believed to play roles in cellular processes related to lipid metabolism, endocytosis, and potentially cell signaling. The presence of class A LDL receptor domains suggests potential involvement in the uptake and clearance of lipoproteins or other ligands, similar to other members of the LDL receptor family. The designation activators implies that compounds within this class interact with LDLRAD2 to modulate its activity, potentially leading to downstream effects on lipid metabolism and cellular processes.

Investigations into LDLRAD2 activators involve elucidating the molecular mechanisms underlying their interaction with the LDLRAD2 protein and how this interaction impacts cellular processes. Understanding the pharmacological properties of these compounds is crucial for deciphering how they affect LDLRAD2 activity and potentially influence lipid metabolism, endocytosis, and cellular signaling. By unraveling the biological functions and regulatory mechanisms of LDLRAD2, researchers aim to deepen our understanding of cellular physiology and may uncover novel insights into the molecular pathways underlying lipid metabolism and related diseases. Continued exploration of LDLRAD2 activators holds promise for advancing our knowledge of lipid biology and may provide insights into new strategies for manipulating cellular function in experimental contexts.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Simvastatin

79902-63-9sc-200829
sc-200829A
sc-200829B
sc-200829C
50 mg
250 mg
1 g
5 g
$30.00
$87.00
$132.00
$434.00
13
(1)

As inhibitors of HMG-CoA reductase, statins lower cholesterol synthesis and might upregulate LDLRAD2 as part of a compensatory mechanism to increase cholesterol uptake.

Fenofibrate

49562-28-9sc-204751
5 g
$40.00
9
(1)

Fibrates activate PPARα and can influence lipid metabolism, potentially affecting the expression of genes involved in LDL processing and transport, including LDLRAD2.

9-cis-Retinoic acid

5300-03-8sc-205589
sc-205589B
sc-205589C
sc-205589D
sc-205589A
1 mg
25 mg
250 mg
500 mg
5 mg
$70.00
$416.00
$3060.00
$5610.00
$145.00
10
(1)

A retinoid that can activate RXR receptors, involved in various metabolic pathways, potentially influencing the expression of genes like LDLRAD2.

25-Hydroxycholesterol

2140-46-7sc-214091B
sc-214091
sc-214091A
sc-214091C
5 mg
10 mg
25 mg
100 mg
$52.00
$89.00
$166.00
$465.00
8
(2)

As an oxysterol involved in cholesterol homeostasis, 25-hydroxycholesterol might modulate the expression of genes related to lipid metabolism, including LDLRAD2.

Cholic acid

81-25-4sc-255020
sc-255020A
sc-255020B
sc-255020C
sc-255020D
25 g
100 g
500 g
1 kg
5 kg
$48.00
$121.00
$567.00
$998.00
$4480.00
11
(1)

Bile acids can signal through nuclear receptors like FXR, potentially influencing the expression of genes involved in lipid metabolism, including LDLRAD2.

Insulin

11061-68-0sc-29062
sc-29062A
sc-29062B
100 mg
1 g
10 g
$153.00
$1224.00
$12239.00
82
(1)

Insulin regulates lipid metabolism and could potentially influence the expression of genes like LDLRAD2 in pathways related to lipid uptake and storage.

L-3,3′,5-Triiodothyronine, free acid

6893-02-3sc-204035
sc-204035A
sc-204035B
10 mg
100 mg
250 mg
$40.00
$75.00
$150.00
(1)

Thyroid hormones influence metabolism and could potentially regulate the expression of genes involved in lipid metabolism, including LDLRAD2.

Cholecalciferol

67-97-0sc-205630
sc-205630A
sc-205630B
1 g
5 g
10 g
$70.00
$160.00
$290.00
2
(1)

Involved in various metabolic processes, Vitamin D3 might influence the expression of genes related to lipid metabolism, including LDLRAD2.

Pioglitazone

111025-46-8sc-202289
sc-202289A
1 mg
5 mg
$54.00
$123.00
13
(1)

As a PPARγ agonist, pioglitazone influences lipid and glucose homeostasis, potentially affecting the expression of genes like LDLRAD2.

Ezetimibe

163222-33-1sc-205690
sc-205690A
25 mg
100 mg
$94.00
$236.00
12
(2)

By inhibiting intestinal cholesterol absorption, ezetimibe might influence hepatic cholesterol metabolism and potentially the expression of genes like LDLRAD2.