LDH-B Inhibitors
The chemical class of LDH-B inhibitors encompasses a diverse array of compounds that specifically target lactate dehydrogenase B (LDH-B), a key enzyme involved in cellular lactate metabolism. These inhibitors can be classified into direct and indirect categories based on their mechanisms of action. Direct inhibitors, such as Gossypol, Oxamate, FX11, Galloflavin, 3-bromopyruvate, and N-Hydroxyindole-2-carboxylate, exert their effects by directly interacting with LDH-B's active site or modifying its catalytic machinery. Gossypol, for instance, binds to the enzyme, disrupting lactate-to-pyruvate conversion. Oxamate competes with pyruvate for the enzyme's active site, interfering with its catalytic function. FX11, on the other hand, directly inhibits LDH-B, providing a specific tool for studying lactate metabolism.
Indirect inhibitors, represented by Sodium Citrate, Quercetin, Sodium Malate, EGCG, and Methylglyoxal, modulate LDH-B activity through alternative pathways. Sodium Citrate, acting indirectly, influences the cellular microenvironment by serving as a buffer, impacting LDH-B's pH sensitivity. Quercetin and EGCG, both polyphenols, indirectly inhibit LDH-B by affecting signaling pathways like PI3K/Akt/mTOR, providing insights into the intricate regulatory mechanisms governing lactate metabolism. Sodium Malate and Methylglyoxal, as indirect inhibitors, alter the cellular redox state and glycolytic processes, respectively, influencing LDH-B activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Gossypol | 303-45-7 | sc-200501 sc-200501A | 25 mg 100 mg | $116.00 $230.00 | 12 | |
Gossypol acts as a direct inhibitor of LDH-B by binding to its active site, disrupting the enzymatic activity. This compound interferes with the catalytic function of LDH-B, preventing the conversion of lactate to pyruvate. | ||||||
Oxamic acid | 471-47-6 | sc-250620 | 25 g | $148.00 | ||
Oxamic acid serves as a direct inhibitor of LDH-B by competitively inhibiting the binding of pyruvate to the enzyme's active site. This competitive inhibition impedes the conversion of lactate to pyruvate, effectively suppressing LDH-B activity. | ||||||
2,3-Dihydroxy-6-methyl-7-(phenylmethyl)-4-propyl-1-naphthalenecarboxylic Acid | 213971-34-7 | sc-498807 | 1 mg | $480.00 | ||
Also called FX11, this compound is a direct inhibitor of LDH-B, disrupting its enzymatic activity by interfering with the conversion of lactate to pyruvate. By specifically targeting LDH-B, FX11 provides a selective approach for modulating lactate metabolism. | ||||||
Galloflavin | 568-80-9 | sc-489548 | 10 mg | $380.00 | ||
Galloflavin acts as a direct inhibitor of LDH-B by disrupting its catalytic activity. This compound interferes with the conversion of lactate to pyruvate, providing a targeted approach to inhibit LDH-B function. | ||||||
Sodium oxalate | 62-76-0 | sc-203396 sc-203396A | 100 g 500 g | $43.00 $139.00 | 5 | |
Sodium oxalate serves as a direct inhibitor of LDH-B by competitively inhibiting the enzyme's active site, interfering with the conversion of lactate to pyruvate. | ||||||
Citric Acid Trisodium Salt | 68-04-2 | sc-214745 sc-214745A sc-214745B sc-214745C | 100 g 500 g 1 kg 5 kg | $41.00 $61.00 $82.00 $321.00 | ||
Sodium citrate serves as an indirect inhibitor of LDH-B by influencing the cellular microenvironment. It acts as a buffer, maintaining a higher pH that can impact LDH-B activity. The altered pH conditions affect the enzymatic activity of LDH-B, providing an indirect approach to modulate lactate metabolism. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin acts as an indirect inhibitor of LDH-B by modulating cellular signaling pathways. It affects the PI3K/Akt/mTOR pathway, which, in turn, influences LDH-B activity. The downstream effects on lactate metabolism make quercetin an indirect inhibitor with potential implications for cancer metabolism and other cellular processes. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate (EGCG) acts as an indirect inhibitor of LDH-B by impacting cellular signaling pathways. It influences the PI3K/Akt/mTOR pathway, which, in turn, modulates LDH-B activity. | ||||||
Methylglyoxal solution | 78-98-8 | sc-250394 sc-250394A sc-250394B sc-250394C sc-250394D | 25 ml 100 ml 250 ml 500 ml 1 L | $146.00 $437.00 $478.00 $754.00 $1446.00 | 3 | |
Methylglyoxal serves as an indirect inhibitor of LDH-B by influencing cellular glycolysis. It forms adducts with cellular proteins, including LDH-B, affecting its enzymatic activity. The modified protein structure hinders LDH-B activity, providing an indirect approach to modulate lactate metabolism. | ||||||