Latrophilin-2 Activators
Latrophilin-2, also known as ADGRL2, is a member of the G-protein coupled receptor family. Latrophilin-2 Activators comprises compounds that can influence its activity, either directly or through associated cellular pathways.
Among the prominent members of this class is cAMP, a secondary messenger pivotal in numerous cellular functions. Elevated cAMP levels can enhance ADGRL2-associated pathways, with Forskolin serving as an agent capable of inducing this elevation. Neurotransmitters such as Epinephrine and Norepinephrine, by modulating the activity of G-protein coupled receptors, can similarly exert influence on ADGRL2-related pathways. Isoproterenol, a synthetic agonist of beta-adrenergic receptors, presents another mechanism of indirect modulation by affecting these receptors. On the other hand, Acetylcholine's interactions with muscarinic receptors offer yet another avenue for influencing GPCRs activity connected to ADGRL2. Furthermore, extracellular signals like ATP and UTP, through their action on purinergic receptors, can impact pathways that may intersect with ADGRL2 activity. The role of GTPγS, a non-hydrolyzable GTP analogue, is of significance as it can activate G-proteins that in turn affect GPCRs. Lastly, PGE2, by engaging with EP receptors, and SQ 22,536, an adenylate cyclase inhibitor, alongside 8-Br-cAMP, a membrane-permeable cAMP analog, represent diverse mechanisms by which cellular pathways relevant to ADGRL2 can be modulated.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
cAMP is a secondary messenger involved in many cellular processes. An increase in cAMP levels can indirectly enhance ADGRL2-associated pathways. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin elevates intracellular cAMP levels, potentially influencing pathways in which ADGRL2 is involved. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Being a neurotransmitter, it can influence G-protein coupled receptors (GPCRs) activity, including possibly ADGRL2. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $326.00 $485.00 | 3 | |
Similar to epinephrine, norepinephrine can modulate GPCRs, indirectly affecting ADGRL2-related pathways. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a synthetic agonist of beta-adrenergic receptors. Its influence on these receptors might indirectly modulate ADGRL2 activity. | ||||||
Adenosine 5′-Triphosphate, disodium salt | 987-65-5 | sc-202040 sc-202040A | 1 g 5 g | $39.00 $75.00 | 9 | |
ATP, as an extracellular signal, can affect purinergic receptors which might indirectly interact with pathways involving ADGRL2. | ||||||
Uridine-5′-triphosphate, Trisodium Salt | 19817-92-6 | sc-301964 sc-301964A | 50 mg 1 g | $88.00 $120.00 | 2 | |
Similar to ATP, UTP's role as an extracellular signal might have an indirect influence on ADGRL2. | ||||||
Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt | 94825-44-2 | sc-202639 | 10 mg | $465.00 | ||
A non-hydrolyzable GTP analogue can activate G-proteins and indirectly influence GPCRs, including possibly ADGRL2. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 influences multiple signaling pathways via its interaction with EP receptors, which can have a downstream effect on ADGRL2-associated pathways. | ||||||
SQ 22536 | 17318-31-9 | sc-201572 sc-201572A | 5 mg 25 mg | $95.00 $363.00 | 13 | |
An adenylate cyclase inhibitor. By modulating cAMP levels, it can indirectly affect ADGRL2-associated pathways. | ||||||