LAMP-2 Inhibitors
Lysosome-associated membrane protein 2 (LAMP-2) inhibitors constitute a distinctive category within the realm of chemical compounds designed to interact with cellular components. These inhibitors primarily target LAMP-2, a vital protein present in lysosomal membranes. LAMP-2 plays a pivotal role in regulating the lysosomal environment and facilitating the transport of molecules within the lysosome. The inhibitors designed to interact with LAMP-2 typically possess specific molecular structures that enable them to interact with the protein and modulate its function. These compounds often display a high degree of selectivity for LAMP-2, allowing them to elicit precise effects on lysosomal dynamics.
Inhibiting LAMP-2 involves the disruption of essential cellular processes linked to lysosomal function. LAMP-2 is integral to autophagy, the cellular process responsible for degrading and recycling intracellular components. LAMP-2 inhibitors, by affecting the function of this protein, can influence autophagy-related pathways, thereby influencing cellular homeostasis.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Inhibits lysosome function and autophagy, affecting LAMP-2 function. | ||||||
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $56.00 | 1 | |
Similar to chloroquine, interferes with lysosome activity, affecting LAMP-2 function | ||||||
Danoprevir | 850876-88-9 | sc-364480 sc-364480A | 5 mg 50 mg | $320.00 $1950.00 | ||
LAMP-2 inhibition through modulation of autophagy pathways. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Lysosomotropic compound, inhibits lysosome acidification and LAMP-2. | ||||||
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $72.00 $145.00 $265.00 $489.00 $1399.00 $99.00 | 19 | |
Protease inhibitor affecting lysosomal protein degradation via LAMP-2. | ||||||
Azelastine | 58581-89-8 | sc-337544 sc-337544A sc-337544B | 100 mg 500 mg 1 g | $220.00 $550.00 $700.00 | ||
Lysosomal disruption and impairment of LAMP-2 function. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
Indirectly impairs lysosomal function by targeting Hsp90. | ||||||
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $275.00 $928.00 $1543.00 | 14 | |
Calpain and cathepsin inhibitor affecting lysosomal activity. | ||||||
Concanamycin A | 80890-47-7 | sc-202111 sc-202111A sc-202111B sc-202111C | 50 µg 200 µg 1 mg 5 mg | $65.00 $162.00 $650.00 $2550.00 | 109 | |
Binds V-ATPase, leading to lysosomal acidification disruption. | ||||||
CA-074 | 134448-10-5 | sc-202513 | 1 mg | $315.00 | ||
Selective cathepsin B inhibitor, affecting lysosomal processes. | ||||||