Lamin A Activators
The chemical class known as Lamin A activators encompasses a diverse array of compounds that either directly activate Lamin A or indirectly influence its expression through modulation of various cellular pathways. Lamin A, a crucial component of the nuclear lamina, plays a pivotal role in maintaining nuclear structure, chromatin organization, and cellular functions. The identified chemicals in this class target key cellular processes, highlighting the intricate interplay between chromatin dynamics and nuclear architecture. Several compounds, such as Roscovitine, Tubastatin A, and Trichostatin A, indirectly activate Lamin A by influencing cell cycle progression and chromatin structure. Roscovitine, a cyclin-dependent kinase (CDK) inhibitor, arrests the cell cycle in G1 phase, promoting the expression of Lamin A and contributing to nuclear envelope integrity. Tubastatin A and Trichostatin A, inhibitors of histone deacetylases (HDACs), alter chromatin structure through histone acetylation, indirectly regulating Lamin A expression and influencing nuclear architecture. Another group of compounds, including GSK343, JQ1, and EPZ-6438, indirectly activates Lamin A by modulating histone methylation. These compounds target histone lysine methyltransferases and bromodomain proteins, influencing chromatin accessibility and gene expression, ultimately impacting Lamin A levels and nuclear envelope integrity.
The chemical class also includes inhibitors of murine double minute 2 (MDM2) such as Nutlin-3, which indirectly activates Lamin A by disrupting the MDM2-p53 interaction. Stabilization of p53 leads to increased expression of Lamin A, connecting cellular stress response pathways with nuclear structure maintenance. Additionally, compounds like UNC1999, Panobinostat, GSK-J4, and Chaetocin, targeting histone lysine methyltransferases and demethylases, further highlight the role of epigenetic modifications in regulating Lamin A expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine, a cyclin-dependent kinase (CDK) inhibitor, indirectly activates Lamin A by inhibiting CDKs, particularly CDK1 and CDK2. CDKs regulate cell cycle progression, and their inhibition by Roscovitine leads to cell cycle arrest in G1 phase. This arrest promotes the expression of Lamin A, contributing to nuclear envelope integrity and chromatin organization. | ||||||
Tubastatin A | 1252003-15-8 | sc-507298 | 10 mg | $114.00 | ||
Tubastatin A, a histone deacetylase 6 (HDAC6) inhibitor, indirectly activates Lamin A by modulating chromatin structure. HDAC6 inhibition by Tubastatin A results in increased acetylation of histones, influencing nuclear architecture and gene expression. This modulation contributes to the regulation of Lamin A expression, affecting nuclear envelope integrity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A, a histone deacetylase (HDAC) inhibitor, indirectly activates Lamin A by promoting histone acetylation. HDAC inhibition alters chromatin structure, leading to increased acetylation of histones and influencing gene expression, including that of Lamin A. The modulation of chromatin by Trichostatin A contributes to the maintenance of nuclear architecture and the regulation of Lamin A levels. | ||||||
GSK343 | 1346704-33-3 | sc-397025 sc-397025A | 5 mg 25 mg | $151.00 $461.00 | 1 | |
GSK343, a histone lysine methyltransferase EZH2 inhibitor, indirectly activates Lamin A by influencing histone methylation. Inhibition of EZH2, a key enzyme in histone methylation, results in altered chromatin structure and gene expression, including that of Lamin A. The modulation of histone methylation by GSK343 contributes to the regulation of Lamin A levels, impacting nuclear envelope integrity and cellular functions. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1, a bromodomain and extraterminal (BET) protein inhibitor, indirectly activates Lamin A by modulating chromatin accessibility. BET proteins play a role in chromatin remodeling, and their inhibition by JQ1 alters the accessibility of chromatin, influencing gene expression, including that of Lamin A. The modulation of chromatin accessibility by JQ1 contributes to the regulation of Lamin A levels, impacting nuclear envelope integrity and cellular functions. | ||||||
(–)-Nutlin-3 | 675576-98-4 | sc-222086 sc-222086A | 1 mg 5 mg | $122.00 $219.00 | 2 | |
Nutlin-3, a murine double minute 2 (MDM2) inhibitor, indirectly activates Lamin A by disrupting the MDM2-p53 interaction. Inhibition of MDM2 stabilizes p53, leading to cell cycle arrest and increased expression of Lamin A. The modulation of the MDM2-p53 axis by Nutlin-3 contributes to the regulation of Lamin A levels, impacting nuclear envelope integrity and chromatin organization. | ||||||
EPZ6438 | 1403254-99-8 | sc-507456 | 1 mg | $66.00 | ||
EPZ-6438, a histone lysine methyltransferase EZH2 inhibitor, indirectly activates Lamin A by influencing histone methylation. Inhibition of EZH2, a key enzyme in histone methylation, results in altered chromatin structure and gene expression, including that of Lamin A. The modulation of histone methylation by EPZ-6438 contributes to the regulation of Lamin A levels, impacting nuclear envelope integrity and cellular functions. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Vorinostat, a histone deacetylase (HDAC) inhibitor, indirectly activates Lamin A by promoting histone acetylation. HDAC inhibition alters chromatin structure, leading to increased acetylation of histones and influencing gene expression, including that of Lamin A. The modulation of chromatin by Vorinostat contributes to the maintenance of nuclear architecture and the regulation of Lamin A levels. | ||||||
UNC1999 | 1431612-23-5 | sc-475314 | 5 mg | $142.00 | 1 | |
UNC1999, a histone lysine methyltransferase EZH2 inhibitor, indirectly activates Lamin A by influencing histone methylation. Inhibition of EZH2, a key enzyme in histone methylation, results in altered chromatin structure and gene expression, including that of Lamin A. The modulation of histone methylation by UNC1999 contributes to the regulation of Lamin A levels, impacting nuclear envelope integrity and cellular functions. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
Panobinostat, a histone deacetylase (HDAC) inhibitor, indirectly activates Lamin A by promoting histone acetylation. HDAC inhibition alters chromatin structure, leading to increased acetylation of histones and influencing gene expression, including that of Lamin A. The modulation of chromatin by Panobinostat contributes to the maintenance of nuclear architecture and the regulation of Lamin A levels. | ||||||