Lad Inhibitors
Lad inhibitors are chemical entities that can diminish the functional activity of Lad, a protein involved in the regulation of cell shape via interaction with the actin cytoskeleton and myosin II. These inhibitors cover categories like myosin II inhibitors (Blebbistatin, ML-7, Y-27632), actin polymerization inhibitors (Latrunculin A, Cytochalasin D, Jasplakinolide, Phalloidin, SMIFH2, CK-666), and Rac GTPase inhibitors (EHT 1864, NSC 23766, Wiskostatin). By inhibiting these specific cellular processes and signaling molecules, the inhibitors can influence Lad's function without directly blocking its activity.
Blebbistatin, ML-7, and Y-27632inhibit myosin II or its regulators, leading to a disruption in actomyosin assembly and an impact on Lad-dependent cell shape regulation. On the other hand, Latrunculin A, Cytochalasin D, Jasplakinolide, Phalloidin, SMIFH2, and CK-666 target actin polymerization or depolymerization, thereby affecting the actin cytoskeleton dynamics and subsequently the Lad-mediated cellular processes. For instance, Latrunculin A and Cytochalasin D inhibit actin polymerization and filament elongation, respectively, while Jasplakinolide and Phalloidin stabilize actin filaments to inhibit their depolymerization. SMIFH2 and CK-666, in contrast, inhibit specific regulators of actin polymerization, namely formin and the Arp2/3 complex, respectively.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $179.00 $307.00 $455.00 $924.00 $1689.00 | 7 | |
Blebbistatin is a specific inhibitor of myosin II, a motor protein that plays a key role in cellular contraction. Lad has been shown to interact with actomyosin complexes to control cell shape. Blebbistatin, by inhibiting myosin II, can disrupt actomyosin assembly and, as a result, affect Lad-dependent cell shape regulation. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Latrunculin A is a potent actin polymerization inhibitor. Lad's function is closely tied to the actin cytoskeleton, and by inhibiting actin polymerization, Latrunculin A can disrupt the normal functioning of Lad in controlling cell shape. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Cytochalasin D is an inhibitor of actin filament elongation. Given Lad's involvement in the actin cytoskeleton, inhibition of actin filament elongation by Cytochalasin D can impact Lad's ability to control cell shape. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
ML-7 is a selective inhibitor of myosin light chain kinase (MLCK), a key regulator of myosin II activity. Inhibition of MLCK can affect myosin II activity and, in turn, Lad-dependent cell shape regulation. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a selective inhibitor of ROCK, a kinase that regulates myosin II through phosphorylation. By inhibiting ROCK, Y-27632 can disrupt the normal functioning of Lad in myosin II-mediated cell shape regulation. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Jasplakinolide is an actin stabilizer, preventing actin depolymerization. Because Lad's function is closely tied to the actin cytoskeleton, stabilizing actin with Jasplakinolide can disrupt the normal dynamics of the actin cytoskeleton, affecting Lad's function. | ||||||
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $229.00 | 33 | |
Phalloidin is a toxin that binds and stabilizes actin filaments, preventing their depolymerization. By stabilizing actin filaments, Phalloidin can disrupt the dynamics of the actin cytoskeleton and subsequently the Lad-dependent regulation of cell shape. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
SMIFH2 is a specific inhibitor of formin, a group of proteins that nucleate and elongate actin filaments. Given Lad's involvement in the actin cytoskeleton, inhibition of formin can impact Lad's ability to control cell shape. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $315.00 $1020.00 | 5 | |
CK-666 is a specific inhibitor of the Arp2/3 complex, a key regulator of actin polymerization. Inhibition of the Arp2/3 complex can disrupt actin dynamics and, in turn, Lad-dependent cell shape regulation. | ||||||
EHT 1864 | 754240-09-0 | sc-361175 sc-361175A | 10 mg 50 mg | $209.00 $872.00 | 12 | |
EHT 1864 is a Rac GTPase inhibitor. Rac GTPases regulate actin cytoskeleton dynamics, and their inhibition can affect Lad-dependent cell shape regulation. | ||||||