LACTB2 Inhibitors
Chemical inhibitors of LACTB2 can inhibit the protein through various mechanisms that target the mitochondrial environment where LACTB2 is operative. Benzethonium chloride disrupts membrane integrity; this disruption can compromise mitochondrial membrane potential, an environment critical for LACTB2's function in mitochondrial lipid metabolism. Chlorpromazine, by accumulating in mitochondria, alters mitochondrial functions, thus impairing the mitochondrial milieu necessary for LACTB2's activity. Trifluoperazine, acting as a calmodulin antagonist, inhibits LACTB2 by interfering with calcium signaling pathways, essential for mitochondrial processes that LACTB2 participates in. Propranolol, a beta-blocker, concentrates within mitochondria and can alter their function, thereby disrupting the context in which LACTB2 operates.
Additionally, Tamoxifen, known for its mitochondrial effects, can inhibit LACTB2 by causing mitochondrial dysfunction. Oligomycin A and Antimycin A target mitochondrial ATP synthase and complex III, respectively, reducing mitochondrial membrane potential, essential for LACTB2's role. This leads to an energy supply depletion and an altered mitochondrial environment, indirectly inhibiting LACTB2's activity. Rotenone, by inhibiting mitochondrial complex I, disrupts overall mitochondrial function, affecting LACTB2. Zinc pyrithione induces oxidative stress, disrupting mitochondrial function and inhibiting LACTB2's role in mitochondrial lipid metabolism. Allicin's interference with thiol-containing enzymes in mitochondria can inhibit LACTB2 by affecting its structural integrity. Betulinic acid induces mitochondrial membrane permeabilization, affecting the environment where LACTB2 functions. Lastly, Cerulenin inhibits fatty acid synthase, an enzyme crucial for lipid metabolism, thereby indirectly inhibiting LACTB2's activity within the same metabolic pathway. Each of these chemicals, by targeting specific mitochondrial processes or environments, can inhibit LACTB2's functionality within mitochondrial lipid metabolism.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Benzethonium chloride | 121-54-0 | sc-239299 sc-239299A | 100 g 250 g | $53.00 $105.00 | 1 | |
Benzethonium chloride is a quaternary ammonium compound which may disrupt membrane integrity. Inhibition of LACTB2 can occur due to the compromised mitochondrial membrane potential, as LACTB2 is associated with mitochondrial function. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Chlorpromazine is a cationic amphiphilic drug known to accumulate in mitochondria and alter mitochondrial functions. Since LACTB2 is involved in mitochondrial lipid metabolism, chlorpromazine can inhibit LACTB2 by impairing the mitochondrial environment where LACTB2 operates. | ||||||
Trifluoperazine Dihydrochloride | 440-17-5 | sc-201498 sc-201498A | 1 g 5 g | $56.00 $99.00 | 9 | |
Trifluoperazine is a calmodulin antagonist and can indirectly inhibit LACTB2 by interfering with calcium signaling, which is essential for various mitochondrial processes including those associated with LACTB2 function. | ||||||
Propranolol | 525-66-6 | sc-507425 | 100 mg | $180.00 | ||
Propranolol, a beta-blocker, can concentrate within mitochondria and alter mitochondrial function, thus potentially inhibiting LACTB2 activity by disrupting its mitochondrial context. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $256.00 | 18 | |
Tamoxifen, an estrogen receptor modulator, is known to have mitochondrial effects and could inhibit LACTB2 by causing mitochondrial dysfunction and impairing the environment necessary for LACTB2's activity. | ||||||
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $175.00 $600.00 $1179.00 $5100.00 $9180.00 | 26 | |
Oligomycin A inhibits mitochondrial ATP synthase. Since LACTB2 is involved in mitochondrial lipid metabolism, inhibition of ATP synthase can indirectly inhibit LACTB2 by depleting the energy supply required for its function. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
Antimycin A is an inhibitor of mitochondrial complex III. Inhibiting this complex can lead to a reduction in mitochondrial membrane potential, indirectly inhibiting LACTB2 by altering the mitochondrial environment. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone is an inhibitor of mitochondrial complex I. By inhibiting complex I, rotenone can disrupt mitochondrial function, which may indirectly inhibit LACTB2 by affecting the mitochondria. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc pyrithione can disrupt mitochondrial function and induce oxidative stress. This disruption can inhibit LACTB2 activity by altering the mitochondrial environment and affecting mitochondrial lipid metabolism. | ||||||
Allicin | 539-86-6 | sc-202449 sc-202449A | 1 mg 5 mg | $460.00 $1428.00 | 7 | |
Allicin is known to interfere with thiol-containing enzymes in mitochondria. As LACTB2 has a role in mitochondrial lipid metabolism, allicin can inhibit LACTB2 by interfering with its thiol groups. | ||||||