L-type Ca++ CP α1D Activators
The term L-type Ca++ CP α1D Activators refers to a class of chemicals that either directly or indirectly enhance the function of the L-type calcium channel protein α1D. The diversity of these activators, which includes dihydropyridine derivatives, catecholamines, diterpenes, phosphodiesterase inhibitors, neurosteroids, and neurotransmitters, underscores the broad range of cellular processes that can influence the activity of this protein. Direct activators such as Bay K 8644 and pregnenolone sulfate bind to specific sites on L-type calcium channels, potentiating their opening and leading to increased calcium influx. The action of Bay K 8644 is of particular interest due to its allosteric mechanism, highlighting how changes in the physical conformation of the L-type Ca++ CP α1D can significantly impact its function.
Indirect activators operate through a variety of signaling pathways to modulate the activity of L-type calcium channels. Cyclic AMP is a key intermediary in many of these pathways. Chemicals such as (-)-epinephrine, forskolin, 1,9-dideoxyforskolin, and isoproterenol, all increase cyclic AMP levels, either through the direct activation of adenylate cyclase or through the stimulation of beta-adrenergic receptors. Increased cyclic AMP in turn activates protein kinase A, which phosphorylates and enhances the activity of L-type calcium channels. Other indirect activators, such as IBMX and 8-Bromo-cAMP, operate by inhibiting the degradation of cyclic AMP, thereby prolonging its effects. Another route of indirect activation is via neurotransmitters such as dopamine, glutamate, and histamine, which can influence the activity of L-type calcium channels through their action on various receptors and signaling pathways. In summary, L-type Ca++ CP α1D activators represent a diverse array of chemicals that can enhance the function of L-type calcium channels through their direct or indirect actions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $84.00 $196.00 $817.00 | ||
Bay K 8644 is a dihydropyridine derivative that acts as a direct allosteric activator of L-type calcium channels. It binds to a site distinct from the dihydropyridine receptor, potentiating the opening of these channels and leading to increased calcium influx. Consequently, this activates the L-type Ca++ CP α1D directly. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
(-)-Epinephrine is a catecholamine that binds to and activates beta-adrenergic receptors. The subsequent activation of the cyclic AMP pathway leads to the phosphorylation of L-type calcium channels, which increases their activity and indirectly activates the L-type Ca++ CP α1D. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a labdane diterpene that activates adenylate cyclase, increasing cyclic AMP levels. This leads to the activation of protein kinase A, which then phosphorylates and activates the L-type calcium channels, indirectly activating the L-type Ca++ CP α1D. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, preventing the breakdown of cyclic AMP and cyclic GMP. The increased cyclic AMP levels lead to the activation of protein kinase A, which phosphorylates and activates L-type calcium channels, indirectly activating the L-type Ca++ CP α1D. | ||||||
Pregnenolone sulfate sodium salt | 1852-38-6 | sc-301609 | 50 mg | $99.00 | 2 | |
Pregnenolone sulfate is a neurosteroid that potentiates the activity of L-type calcium channels. It binds to a site on these channels, increasing their open probability and leading to enhanced calcium influx, which directly activates the L-type Ca++ CP α1D. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates protein kinase A. The activated protein kinase A phosphorylates and activates L-type calcium channels, indirectly activating the L-type Ca++ CP α1D. | ||||||
1,9-Dideoxyforskolin | 64657-18-7 | sc-201560 sc-201560A | 1 mg 5 mg | $98.00 $325.00 | 1 | |
1,9-Dideoxyforskolin is a forskolin analog that activates adenylate cyclase, increasing cyclic AMP levels. This leads to the activation of protein kinase A, which phosphorylates and activates the L-type calcium channels, indirectly activating the L-type Ca++ CP α1D. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a synthetic catecholamine that activates beta-adrenergic receptors. The subsequent activation of the cyclic AMP pathway leads to the phosphorylation of L-type calcium channels, which increases their activity and indirectly activates the L-type Ca++ CP α1D. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine is a neurotransmitter that activates dopamine receptors which can increase cyclic AMP levels. This leads to the activation of protein kinase A, which phosphorylates and activates the L-type calcium channels, indirectly activating the L-type Ca++ CP α1D. | ||||||
L-Glutamic Acid | 56-86-0 | sc-394004 sc-394004A | 10 g 100 g | $297.00 $577.00 | ||
Glutamate is an excitatory neurotransmitter that activates NMDA receptors, leading to calcium influx. This can indirectly increase the activity of L-type calcium channels and thus the L-type Ca++ CP α1D. | ||||||