Molecular structure of 1,9-Dideoxyforskolin, CAS Number: 64657-18-7
1,9-Dideoxyforskolin (CAS 64657-18-7)
See product citations (1)
Alternate Names:
7β-Acetoxy-6β-hydroxy-8,13-epoxy-labd-14-en-11-one
Application:
1,9-Dideoxyforskolin is a Forskolin analog that does not activate adenylate cyclase
CAS Number:
64657-18-7
Purity:
≥95%
Molecular Weight:
378.50
Molecular Formula:
C22H34O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
1,9-Dideoxyforskolin is a derivative of Forskolin (sc-3562) which unlike the parent compound is incapable of activating adenylate cyclase. Forskolin-induced stimulation of adenylate cyclase and increased cAMP levels is employed to study the modulation of ion channels and cAMP-dependent second messenger systems, and 1,9-Dideoxyforskolin serves as a negative control for cAMP-related Forskolin inductions. 1,9-Dideoxyforskolin mimics some activity of Forskolin, demonstrating alteration of K+ channel activity, reversal of doxorubicin resistance in multidrug resistant sarcoma cells, protection against TNF-α-mediated cytotoxicity, and desensitization at GABAA receptors.
1,9-Dideoxyforskolin (CAS 64657-18-7) References
- Forskolin modulation of desensitization at GABA(A) and glycine receptors is not mediated by cAMP-dependent protein kinase in isolated carp amacrine-like cells. | Li, P. and Yang, XL. 2001. Pflugers Arch. 441: 739-45. PMID: 11316256
- The adenylate cyclase activator forskolin partially protects L929 cells against tumour necrosis factor-alpha-mediated cytotoxicity via a cAMP-independent mechanism. | Uboldi, AD. and Savage, N. 2002. Cytokine. 19: 250-8. PMID: 12393172
- 1,9-Dideoxyforskolin does not mimic all cAMP and protein kinase A independent effects of forskolin on GABA activated ion currents in adult rat sensory neurons. | White, G., et al. 1992. Brain Res. 586: 157-61. PMID: 1380877
- Ca2+-independent, inhibitory effects of cyclic adenosine 5'-monophosphate on Ca2+ regulation of phosphoinositide 3-kinase C2alpha, Rho, and myosin phosphatase in vascular smooth muscle. | Azam, MA., et al. 2007. J Pharmacol Exp Ther. 320: 907-16. PMID: 17110524
- cAMP-dependent kinase does not modulate the Slack sodium-activated potassium channel. | Nuwer, MO., et al. 2009. Neuropharmacology. 57: 219-26. PMID: 19540251
- Extracellular osmolarity modulates G protein-coupled receptor-dependent ATP release from 1321N1 astrocytoma cells. | Blum, AE., et al. 2010. Am J Physiol Cell Physiol. 298: C386-96. PMID: 19907018
- Suppression of GLUT1; a new strategy to prevent diabetic complications. | Lu, L., et al. 2013. J Cell Physiol. 228: 251-7. PMID: 22717959
- Effect of forskolin on voltage-gated K+ channels is independent of adenylate cyclase activation. | Hoshi, T., et al. 1988. Science. 240: 1652-5. PMID: 2454506
- cAMP increases the rate of GABAA receptor desensitization in chick cortical neurons. | Tehrani, MH., et al. 1989. Synapse. 4: 126-31. PMID: 2551053
- Partial reversal of doxorubicin resistance by forskolin and 1,9-dideoxyforskolin in murine sarcoma S180 variants. | Wadler, S. and Wiernik, PH. 1988. Cancer Res. 48: 539-43. PMID: 2825978
- Direct anesthetic-like effects of forskolin on the nicotinic acetylcholine receptors of PC12 cells. | McHugh, EM. and McGee, R. 1986. J Biol Chem. 261: 3103-6. PMID: 3005280
- Chemical characterization and evaluation of the neuroprotective potential of Indigofera sessiliflora through in-silico studies and behavioral tests in scopolamine-induced memory compromised rats. | Sajjad Haider, M., et al. 2021. Saudi J Biol Sci. 28: 4384-4398. PMID: 34354423
- Impact of seasonal variation on four labdane-type diterpenoids in Coleus forskholii Briq. | Chaudhary, MK., et al. 2023. Nat Prod Res. 1-6. PMID: 36695524
Inhibitor of:
Barttin.Activator of:
DUSP12, L-type Ca++ CP α1D, MAST205, and MEK-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1,9-Dideoxyforskolin, 1 mg | sc-201560 | 1 mg | $98.00 | |||
1,9-Dideoxyforskolin, 5 mg | sc-201560A | 5 mg | $325.00 |