1,9-Dideoxyforskolin CAS: 64657-18-7
MF: C22H34O5
MW: 378.50
A Forskolin analog that does not activate adenylate cyclase.

1,9-Dideoxyforskolin (CAS 64657-18-7)

1,9-Dideoxyforskolin | CAS 64657-18-7 is rated 5.0 out of 5 by 1.
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Alternate Names: 7β-Acetoxy-6β-hydroxy-8,13-epoxy-labd-14-en-11-one
Application: 1,9-Dideoxyforskolin is a Forskolin analog that does not activate adenylate cyclase
CAS Number: 64657-18-7
Purity: ≥95%
Molecular Weight: 378.50
Molecular Formula: C22H34O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

1,9-Dideoxyforskolin is a derivative of Forskolin (sc-3562) which unlike the parent compound is incapable of activating adenylate cyclase. Forskolin-induced stimulation of adenylate cyclase and increased cAMP levels is employed to study the modulation of ion channels and cAMP-dependent second messenger systems, and 1,9-Dideoxyforskolin serves as a negative control for cAMP-related Forskolin inductions. 1,9-Dideoxyforskolin mimics some activity of Forskolin, demonstrating alteration of K+ channel activity, reversal of doxorubicin resistance in multidrug resistant sarcoma cells, protection against TNF-α-mediated cytotoxicity, and desensitization at GABAA receptors.


References

1. McHugh, E.M. and McGee, R. 1986. J. Biol. Chem. 261: 3103-3106. PMID: 3005280
2. Wadler, S. and Wiernik, P.H. 1988. Cancer Res. 48: 539-543. PMID: 2825978
3. Hoshi, T., et al. 1988. Science. 240: 1652-1655. PMID: 2454506
4. Tehrani, M.H., et al. 1989. Synapse. 4: 126-131. PMID: 2551053
5. White, G., et al. 1992. Brain Res. 586: 157-161. PMID: 1380877
6. Li, P. and Yang, X.L. 2001. Pflugers Arch. 441: 739-745. PMID: 11316256
7. Uboldi, A.D. and Savage, N. 2002. Cytokine. 19: 250-258. PMID: 12393172

Physical State :
Solid
Derived From :
Coleus forskohlii
Solubility :
Soluble in methanol (28 mg/mL), DMSO (3 mg/mL), and ethanol (6.6 mg/mL). Insoluble in dilute aqueous acid and base.
Storage :
Store at -20° C
Melting Point :
162-163° C
Boiling Point :
~455° C at 760 mmHg (Predicted)
Density :
~1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.52 (Predicted)
Optical Activity :
α26/D +93.6°, c = 6.12 in chloroform (lit.)
IC50 :
Stimulate adenylate cyclase: EC5050 = >1000 µM
pK Values :
pKa: 13.76 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
107948
MDL Number :
MFCD00082318
Beilstein Registry :
5304980

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Certificate of Analysis

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1,9-Dideoxyforskolin (CAS 64657-18-7)  Product Citations

See how others have used 1,9-Dideoxyforskolin (CAS 64657-18-7). Click on the entry to view the PubMed entry .

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PMID: # 30382126  Mayati, A.|Moreau, A.|Le Vée, M.|Bruyère, A.|Jouan, E.|Denizot, C.|Parmentier, Y.|Fardel, O.| et al. 2018. Sci Rep. 8: 16115.

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Rated 5 out of 5 by from Angel Angel-Chavez, LI. et al. (PubMed 25962132) found that in sympathetic neurons forskolin and its derivative 1,9-Dideoxyforskolin, reversibly suppresses the delayed rectifier K+ current. -SCBT Publication Review
Date published: 2015-03-18
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