KV4.1 Activators
KV4.1 Activators are a unique class of compounds that indirectly enhance the function of KV4.1 protein, a member of the voltage-gated potassium channel subfamily D. These activators work by manipulating the charge balance across the cell membrane, affecting the activity of KV4.1 indirectly. For instance, compounds like 4-Aminopyridine and Dendrotoxin I are known to block potassium channels, which subsequently prolongs the action potential and indirectly enhances KV4.1 activity. Similarly, Ambroxol acts as a sodium channel activator, and through the promotion of depolarization, it indirectly enhances the activity of voltage-gated potassium channels like KV4.1.
Other KV4.1 activators like Verapamil, Nifedipine, Nisoldipine, and Felodipine are calcium channel blockers. These compounds lower the intracellular concentration of calcium ions, thus reducing the activity of calcium-dependent potassium channels. This action indirectly enhances the relative contribution of KV4.1. Additionally, some compounds indirectly enhance KV4.1 by altering the overall membrane potential. For example, Retigabine, a KV7 K+ channel opener, and Diazoxide, a KATP channel opener, hyperpolarize the resting membrane potential, thereby increasing the driving force for potassium through KV4.1 channels. Phenytoin and Quinidine, sodium channel blockers, work by prolonging the action potential duration, indirectly enhancing KV4.1 activity. Lastly, Nicorandil, a hybrid of potassium channel opener and nitrate, opens ATP-sensitive potassium channels, altering the overall membrane potential, indirectly enhancing KV4.1 activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
4-Aminopyridine | 504-24-5 | sc-202421 sc-202421B sc-202421A | 25 g 1 kg 100 g | $38.00 $1155.00 $122.00 | 3 | |
A potassium channel blocker that primarily impacts fast voltage-gated K+ channels (KV). By blocking the KV4.1 channels, the repolarization phase of the action potential is slowed, allowing for an increased duration of the action potential, which can increase the activity of KV4.1. | ||||||
Ambroxol hydrochloride | 23828-92-4 | sc-200816 | 1 g | $55.00 | ||
A Na+ channel activator that indirectly increases KV4.1 activity. By activating Na+ channels, it promotes depolarization, which subsequently opens more voltage-gated K+ channels like KV4.1. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
A calcium channel blocker that can indirectly enhance KV4.1 function. By reducing intracellular Ca2+, it decreases the activation of Ca2+-dependent K+ channels, thereby indirectly enhancing the relative contribution of KV4.1. | ||||||
Diazoxide | 364-98-7 | sc-200980 | 1 g | $300.00 | 5 | |
A KATP channel opener that can indirectly enhance the function of KV4.1. By hyperpolarizing the resting membrane potential, it leads to an increase in the driving force for K+ through KV4.1 channels. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
A calcium channel blocker that, by decreasing the intracellular concentration of Ca2+, can indirectly enhance the function of KV4.1 by reducing the activity of Ca2+-dependent K+ channels. | ||||||
5,5-Diphenyl Hydantoin | 57-41-0 | sc-210385 | 5 g | $70.00 | ||
A sodium channel blocker that can indirectly enhance KV4.1 activity by prolonging the duration of the action potential, providing more time for KV4.1-mediated K+ efflux. | ||||||
Quinidine | 56-54-2 | sc-212614 | 10 g | $104.00 | 3 | |
A class I antiarrhythmic agent that blocks sodium and potassium channels. By blocking these channels, it prolongs the duration of the action potential, indirectly enhancing KV4.1. | ||||||
Felodipine | 72509-76-3 | sc-201483 sc-201483A | 10 mg 50 mg | $91.00 $222.00 | 1 | |
Another calcium channel blocker that, by reducing intracellular Ca2+ concentration, can indirectly enhance the function of KV4.1 by decreasing the activation of Ca2+-dependent K+ channels. | ||||||
Nicorandil | 65141-46-0 | sc-200995 sc-200995B sc-200995A sc-200995C | 50 mg 100 mg 250 mg 1 g | $57.00 $98.00 $240.00 $500.00 | 4 | |
A hybrid of potassium channel opener and nitrate. It opens ATP-sensitive potassium channels, altering overall membrane potential, which can indirectly enhance the activity of KV4.1 channels. | ||||||