KRTAP7-1 Inhibitors
KRTAP7-1 inhibitors are a niche category of chemical agents that target Keratin Associated Protein 7-1 (KRTAP7-1). As part of the keratin-associated proteins (KAPs) family, KRTAP7-1 plays a role in the formation and structure of keratin fibers in hair and nails. These proteins are known to interact with keratin intermediate filaments to enhance the mechanical strength and resilience of hair. Inhibitors of KRTAP7-1 are designed to interfere with the normal function of the protein, which may involve binding to keratin filaments or participating in the cross-linking that contributes to fiber toughness. The inhibition of KRTAP7-1 can be achieved by compounds that bind to the protein and prevent its interaction with keratin filaments or by disrupting the complex formation necessary for its structural role.
The design and development of KRTAP7-1 inhibitors require a comprehensive understanding of the protein's structure, including the domains responsible for interaction with keratin fibers. These inhibitors may function by directly competing with KRTAP7-1 for binding sites on keratin or by altering the conformation of KRTAP7-1, making it less capable of forming stable associations with keratin filaments. The development process typically involves the use of high-throughput screening to identify potential inhibitory compounds followed by iterative chemical synthesis to enhance the specificity and binding affinity of these molecules for KRTAP7-1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. By targeting protein kinases involved in hair growth and keratin synthesis, it can indirectly affect KRTAP7-1's interaction with keratins. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
2-APB can alter intracellular calcium levels, which are crucial for various cellular processes, including keratinocyte differentiation. This can disrupt keratin interactions, thereby influencing KRTAP7-1. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide inhibits protein synthesis. By halting keratin protein synthesis, it can indirectly inhibit KRTAP7-1. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, a tyrosine kinase inhibitor, can influence various cellular signaling pathways involved in hair growth and keratin production, affecting KRTAP7-1 indirectly. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
As a ROCK inhibitor, Y-27632 affects pathways associated with hair growth. By modulating these pathways, it can indirectly affect KRTAP7-1's interaction with keratins. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR signaling, which is involved in various cellular processes, including keratinocyte growth and differentiation. This can affect KRTAP7-1 indirectly. | ||||||
Calpeptin | 117591-20-5 | sc-202516 sc-202516A | 10 mg 50 mg | $119.00 $447.00 | 28 | |
As a calpain inhibitor, calpeptin affects calcium-dependent cellular processes. This can impact keratin synthesis and stability, indirectly influencing KRTAP7-1. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
By chelating intracellular calcium, BAPTA-AM can influence calcium-dependent processes in keratinocytes, potentially affecting KRTAP7-1. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin inhibits PI3K, affecting several cellular processes in keratinocytes. This can influence keratin interactions and indirectly KRTAP7-1. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
As an inhibitor of the MAPK/ERK pathway, PD98059 can impact cell differentiation and growth, including that of keratinocytes, indirectly affecting KRTAP7-1. | ||||||