KRTAP6-3 Activators
Keratin-associated protein 6-3 (KRTAP6-3) is one of the many proteins that play a crucial role in the composition of hair fibers. As a member of the KRTAP family, KRTAP6-3 is integral to the formation of the hair shaft, contributing to the strength and resilience of hair. The specific expression patterns of KRTAP6-3 within the hair follicle cells are orchestrated by a complex network of genetic signals and are influenced by the cellular microenvironment. Understanding the regulation of genes like KRTAP6-3 is essential for comprehending hair biology and the mechanisms that govern hair growth and structure. The expression of KRTAP6-3 can be enhanced or suppressed by a variety of internal and external factors, and identifying compounds that upregulate this protein can provide insights into the intricate molecular dance that underlies hair formation.
Certain chemicals have been identified or postulated to act as activators of KRTAP6-3 expression, employing diverse biochemical pathways to exert their effects. For instance, molecules like retinoic acid may induce the protein's expression by engaging with nuclear receptors that trigger the transcription of differentiation-specific genes. Others, such as minoxidil, might encourage the expression of KRTAP6-3 by promoting blood flow, thus enriching hair follicle cells with nutrients and oxygen. Nutritional components like biotin are known to be fundamental to cell proliferation and could, therefore, support the synthesis of proteins necessary for hair structure, including KRTAP6-3. Antioxidants such as epigallocatechin gallate, found in green tea, could foster a protective environment for hair follicle cells, potentially stimulating the production of hair-specific proteins. These compounds, each through a unique mechanism, can contribute to the cellular conditions favorable for the expression of KRTAP6-3, underscoring the complex interplay of genetic and environmental factors in hair biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid might upregulate KRTAP6-3 by binding to retinoic acid receptors that initiate transcription of genes involved in hair follicle development. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
By inhibiting DNA methyltransferases, 5-Aza-2′-Deoxycytidine could potentially initiate the transcriptional activation of KRTAP6-3 by reducing methylation near its promoter region. | ||||||
Minoxidil (U-10858) | 38304-91-5 | sc-200984 sc-200984A | 100 mg 1 g | $68.00 $344.00 | ||
Minoxidil is hypothesized to stimulate KRTAP6-3 expression by expanding blood vessels and increasing nutrient flow to hair follicles, thereby creating an environment conducive to hair protein synthesis. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
As an antioxidant, Epigallocatechin gallate might stimulate KRTAP6-3 expression by protecting hair follicle cells from oxidative stress that could otherwise stifle their protein production capacity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin could stimulate KRTAP6-3 expression through the elevation of intracellular cAMP, which can activate signal transduction pathways leading to hair growth and protein synthesis. | ||||||
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $107.00 | 3 | |
Spironolactone might stimulate the upregulation of KRTAP6-3 by mitigating the effects of DHT on hair follicles, thereby allowing for the normal expression of hair-related proteins. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
This antifungal agent could stimulate KRTAP6-3 expression by improving scalp health and reducing inflammation, which may otherwise inhibit hair protein synthesis. | ||||||
D-(+)-Biotin | 58-85-5 | sc-204706 sc-204706A sc-204706B | 1 g 5 g 25 g | $40.00 $105.00 $326.00 | 1 | |
Biotin may stimulate KRTAP6-3 expression as it is essential for cellular proliferation, which is a prerequisite for the synthesis of structural hair proteins. | ||||||
L-Carnitine | 541-15-1 | sc-205727 sc-205727A sc-205727B sc-205727C | 1 g 5 g 100 g 250 g | $23.00 $33.00 $77.00 $175.00 | 3 | |
L-carnitine may promote KRTAP6-3 expression by enhancing the energy metabolism within hair follicle cells, supporting the anabolic processes that include protein synthesis. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $61.00 $122.00 | 1 | |
Nicotinic Acid could potentially induce KRTAP6-3 expression by increasing cutaneous blood flow, which might improve the delivery of nutrients and oxygen necessary for the synthesis of structural hair proteins. | ||||||