KRTAP6-3 Inhibitors
KRTAP6-3 inhibitors represent a specific class of chemical compounds that target the KRTAP6-3 protein, a member of the keratin-associated protein family. This family plays a key role in the formation of the structural matrix of keratin, a fibrous protein that contributes to the mechanical strength of hair and nails. KRTAP6-3, in particular, is one of many small, cysteine-rich keratin-associated proteins involved in cross-linking keratin intermediate filaments. The inhibitors of KRTAP6-3 act by interfering with the normal function or expression of this protein, thereby affecting the structural properties of keratin matrices. This inhibition could be achieved through various mechanisms, such as direct binding to the protein, altering its conformational structure, or modulating its post-translational modifications.
The development of KRTAP6-3 inhibitors likely involves the identification of small molecules that can interact with the protein's active or regulatory sites. Such inhibitors are typically designed to disrupt the biochemical pathways or protein-protein interactions that involve KRTAP6-3. Structural biology techniques, such as X-ray crystallography or NMR spectroscopy, could be employed to elucidate the binding sites and to design inhibitors that efficiently block the function of this protein. By modifying the interaction networks of keratin-associated proteins, these inhibitors can alter the biomechanical properties of keratinous tissues. Understanding the detailed molecular interactions between KRTAP6-3 and its inhibitors allows for insights into how these proteins contribute to the integrity and assembly of keratin matrices, with potential implications for further research into protein-protein interactions in keratin-related processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This DNA methyltransferase inhibitor could lead to hypomethylation of the KRTAP6-3 gene promoter, resulting in decreased transcriptional activity. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
By selectively binding to GC-rich DNA sequences, Mithramycin A might block the specific transcription factors required for KRTAP6-3 gene activation, thereby reducing its expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
As a histone deacetylase inhibitor, Suberoylanilide Hydroxamic Acid could cause an increase in acetylated histones, leading to a relaxed chromatin structure around the KRTAP6-3 locus and subsequent transcriptional repression. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide may suppress the expression of heat shock proteins, potentially destabilizing transcription factors involved in the expression of the KRTAP6-3 gene, leading to a decrease in its transcription. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
By activating retinoic acid receptors, Retinoic Acid might repress the expression of KRTAP6-3 by promoting the recruitment of co-repressor complexes to the gene's promoter region. | ||||||
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $107.00 | 3 | |
Spironolactone could inhibit aldosterone-mediated transcriptional activation of certain genes and potentially downregulate KRTAP6-3 expression through a similar antagonistic mechanism. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea could inhibit ribonucleotide reductase, leading to a reduction in deoxynucleotide triphosphates, stalling the replication fork, and thereby inhibiting KRTAP6-3 gene transcription during DNA synthesis. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin may repress NF-κB signaling, potentially leading to decreased transcription of KRTAP6-3 if its expression is under the control of NF-κB-responsive elements. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram could reduce KRTAP6-3 expression by forming adducts with DNA and altering the binding of transcriptional machinery to the KRTAP6-3 gene promoter. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $87.00 $224.00 | ||
Arsenic Trioxide could lead to the degradation of transcription factors necessary for KRTAP6-3 expression or interfere with their binding to the promoter, thereby repressing gene transcription. | ||||||