Mithramycin A CAS: 18378-89-7
MF: C52H76O24
MW: 1085.15
A polymerase inhibitor that binds to GC rich sequences located in the minor groove of DNA.

Mithramycin A (CAS 18378-89-7)

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同义词: Aureolic acid;Plicamycin
应用; A polymerase inhibitor that binds to GC rich sequences located in the minor groove of DNA
CAS号码: 18378-89-7
纯度: >96%
分子量: 1085.15
分子式: C52H76O24
* 参考分析证明 大量特定数据 (包括水 含量).
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Mithramycin A is an antibiotic DNA/RNA polymerase and DNA binding transcriptional inhibitor observed to facilitate TNF-α and Fas-ligand induced apoptosis. As a DNA binding transcriptional inhibitor, mithramycin A binds to GC rich sequences located in the minor groove of DNA and is noted to be reversible and Mg2+ dependent. Additionally reported to a block transcriptional activation of the SV40 promoter via competitive binding against Sp1 transcription factor to GC rich areas in the early promoter. Mithramycin A is noted to supress TNF-α induced expression of fractalkine (CX3CL1) mRNA in a dose-dependent manner and to act as an effective differentiation agent of HL60 promyelocytic leukemia cells.


参考文献

1. Ray, R., et al. 1989. J. Clin. Invest. 83: 2003-2007. PMID: 2542379
2. Mir, M.A., et al. 2003. Bioorg. Med. Chem. 11: 2791-2801. PMID: 12788353
3. Ahn, S.Y., et al. 2004. Am. J. Pathol. 164: 1663-1672. PMID: 15111313
4. Leroy, I., et al. 2006. Apoptosis. 11: 113-119. PMID: 16374547
5. Mansilla, S., et al. 2010. Biochem. Pharmacol. 79: 1418-1427. PMID: 20093108

用法 :
Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
物理状态 :
Solid
来源于 :
Streptomyces argillaceus
溶解度 :
Soluble in phosphate buffered saline (1 mg/ml), ethanol, ethyl acetate, lower alcohols, and acetone. Insoluble in water.
保存 :
Store at -20° C
熔点 :
164-170° C
沸点 :
1169.8° C at 760 mmHg (Predicted)
密度 :
~1.5 g/cm3 (Predicted)
折射率 :
n20D 1.64
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
PZ2800000
PubChem CID :
230076
默克索引 :
14: 7536
MDL 号码 :
MFCD00135618
Beilstein 注册 :
5236667
SMILES :
CC1C(C(CC(O1)OC2CC(OC(C2O)C)OC3=CC4=CC5=C(C(=O)C(C(C5)C(C(=O)C(C(C)O)O)OC)OC6CC(C(C(O6)C)O)OC7CC(C(C(O7)C)O)OC8CC(C(C(O8)C)O)(C)O)C(=C4C(=C3C)O)O)O)O

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引用1 - 44

PMID: # 29778644  Hepp, MI. et al. 2018. Biochim. Biophys. Acta.

PMID: # 29344898  2018. Methods Mol. Biol. 1711: 351-398.

PMID: # 26908121  Bai, D. et al. 2016. Scientific reports. 6: 22068.

PMID: # 26317415  Okoro, EU. et al. 2015. PLoS ONE. 10: e0136895.

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