Retinoic Acid, all trans CAS: 302-79-4
MF: C20H28O2
MW: 300.4
An activator of RAR and RXR and used in stem cells.

Retinoic Acid, all trans (CAS 302-79-4)

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同义词: Vitamin A acid
应用; An activator of RAR and RXR and used in stem cells
CAS号码: 302-79-4
纯度: ≥98%
分子量: 300.4
分子式: C20H28O2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* 参考分析证明 大量特定数据 (包括水 含量).
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Retinoic Acid, all trans is the oxidized carboxylic acid form of retinol, known in the dietary context as Vitamin A. Retinal (sc-210778) is the aldehyde form of retinol required by the retina of the eye for light absorption and visual processing. Retinoic acid and the other retinoids are involved in a broad range of biological regulations, mediating differentiation, proliferation, and apoptosis. Binding of Retinoic Acid to the nuclear receptors RAR (retinoic acid receptor) and the RXR (retinoid X receptor) initiate signals for transcription and development. The intimate relationship between retinoids and cell cycle regulation has been implicated in suppression of oncogenic proliferation. Also available in a photoactivatable, caged form (sc-202089).


参考文献

1. Leid, M., et al., 1992. Multiplicity generates diversity in the retinoic acid signalling pathways. Trends in biochemical sciences. 17(10): 427-33. PMID: 1333659
2. Allenby, G., et al., 1994. Binding of 9-cis-retinoic acid and all-trans-retinoic acid to retinoic acid receptors alpha, beta, and gamma. Retinoic acid receptor gamma binds all-trans-retinoic acid preferentially over 9-cis-retinoic acid. The Journal of biological chemistry. 269(24): 16689-95. PMID: 8206989
3. Napoli, J L., et al., 1996. Biochemical pathways of retinoid transport, metabolism, and signal transduction. Clinical immunology and immunopathology. 80(3 Pt 2): S52-62. PMID: 8811064
4. Bushue, Nathan., et al., 2010. Retinoid pathway and cancer therapeutics. Advanced drug delivery reviews. 62(13): 1285-98. PMID: 20654663

物理状态 :
Solid
溶解度 :
Soluble in DMSO (25 mg/mL), ethanol (10 mg/mL), acetate, DMF (20 mg/mL), dimethyl sulfoxide (25 mg/mL), chloroform (40 mg/mL), methanol, acetone (30 mg/mL), and dichloromethane. Insoluble in water, and ether. It is recommended that solutions be made fresh for each use.
保存 :
Store at -20° C
熔点 :
180-181° C (lit.)
沸点 :
~462.80° C at 760 mmHg (Predicted)
密度 :
1.01 g/cm3
折射率 :
n20D 1.56
IC50 :
Retinoic acid receptor gamma: IC50 = 0.62 nM (human); Retinoic acid receptor alpha: IC50 = 5 nM (mus musculus); Herpesvirus 4: IC50 = 15.4 nM (human)
Ki 数据 :
Retinoic acid receptor gamma: Ki= 0.7 nM (human); Retinoic acid receptor beta: Ki= 0.5 nM (human); Retinoic acid receptor alpha: Ki= 0.1 nM (human)
pK值 :
pKa: 4.73
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
2
RTECS :
VH6475000
PubChem CID :
444795
默克索引 :
14: 8165
MDL 号码 :
MFCD00001551
EC号码 :
206-129-0
Beilstein 注册 :
2057223
SMILES :
CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/C(=O)O)/C)/C

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PMID: # 29072505  Pastorková, B. et al. 2017. Drug Chem Toxicol. 41: 1-7.

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PMID: # 18511453  Wang, C. et al. 2008. J. Biochem. 144: 313-321.

PMID: # 18280257  Kiningham, KK. et al. 2008. Free Radic. Biol. Med. 44: 1610-1616.

PMID: # 17596541  Soriano, AO. et al. 2007. Blood. 110: 2302-2308.

PMID: # 17283134  Ohnuma-Ishikawa, K. et al. 2007. Cancer Res. 67: 1019-1029.

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