KRTAP5-10 Inhibitors
KRTAP5-10 inhibitors encompass a range of chemical compounds that interact with various cellular signaling pathways and biological processes to exert an inhibitory effect on the function of KRTAP5-10. Staurosporine, a broad-spectrum protein kinase inhibitor, acts by reducing phosphorylation levels within the cell, including those on keratin proteins, which could diminish the functional role of KRTAP5-10 in maintaining hair shaft integrity. Similarly, genistein, by impeding tyrosine kinase activity, can alter the phosphorylation state of proteins that interact with or regulate KRTAP5-10, resulting in decreased activity. Lithium chloride, through its inhibitory action on GSK-3β, modifies the phosphorylation landscape, which can affect KRTAP5-10 associated structures and function. MEK inhibitors like U0126 and PD98059, by interfering with the MAPK/ERK pathway, can indirectly influence the expression and activity of KRTAP5-10.
The indirect inhibition of KRTAP5-10 is further supported by compounds such as rapamycin, an mTOR inhibitor, which reduces protein synthesis and may lower the levels of KRTAP5-10 in hair follicles. Trichostatin A, by altering chromatin structure and gene expression, can change the protein composition within cells, potentially leadingto a downregulation of KRTAP5-10. ROCK inhibitor Y-27632 may destabilize cytoskeletal dynamics, influencing the structural integrity of keratin filaments that KRTAP5-10 is associated with. Inhibitors targeting stress-related kinases, such as SP600125 for JNK and SB203580 for p38 MAPK, could lead to alterations in the cellular processes that indirectly govern the activity of KRTAP5-10. LY294002, as a PI3K inhibitor, disrupts critical signal transduction mechanisms that can have downstream effects on the synthesis and stability of proteins like KRTAP5-10.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, including PKC, which phosphorylates keratin proteins affecting their organization. Inhibition of PKC by staurosporine can lead to reduced phosphorylation and consequent activity of KRTAP5-10. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that could impede the phosphorylation of intracellular proteins. Phosphorylation status can affect the structural integrity of keratin filaments, and thus, genistein may indirectly inhibit KRTAP5-10 function. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3β, a kinase involved in the phosphorylation of various proteins. Through the inhibition of GSK-3β, the structural dynamics of keratins may be altered, leading to potential inhibition of KRTAP5-10. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 functions as a MEK inhibitor, impeding the MAPK/ERK pathway. This pathway can influence keratin expression and function; thus, U0126 may indirectly inhibit KRTAP5-10 activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a kinase that regulates protein synthesis and cell growth. By inhibiting mTOR, rapamycin can reduce the synthesis of various proteins, potentially including KRTAP5-10, to decrease its activity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor, which can alter the expression of various genes by affecting chromatin structure. This can lead to changes in protein composition, indirectly inhibiting KRTAP5-10. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a ROCK inhibitor, which may influence cytoskeleton dynamics and thereby affect the structural integrity and function of intermediate filaments, such as keratins, potentially inhibiting KRTAP5-10. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
SP600125 is an inhibitor of JNK, which is involved in the regulation of various cellular processes, including protein synthesis. JNK inhibition can lead to altered protein function, potentially inhibiting KRTAP5-10 indirectly. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor, which can affect inflammatory response and cellular stress pathways, potentially influencing the function of keratin-associated proteins like KRTAP5-10. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, which can disrupt signal transduction pathways that regulate protein synthesis and cell survival, potentially leading to decreased activity of KRTAP5-10. | ||||||