KRTAP20-3 Inhibitors
KRTAP20-3 inhibitors comprise a diverse group of chemicals that specifically target key signaling pathways associated with KRTAP20-3 activation. These inhibitors act on various points in the signaling cascade, disrupting the phosphorylation events and protein-protein interactions crucial for KRTAP20-3 functionality. Staurosporine, SB203580, and U0126, for instance, target protein kinases, inhibiting the MAPK/ERK and p38 MAP kinase pathways implicated in KRTAP20-3 activation. LY294002 and Wortmannin disrupt the PI3K/Akt pathway, while Rapamycin targets mTOR, affecting another critical pathway linked to KRTAP20-3. Additionally, SP600125 and PD98059 inhibit JNK and MEK, respectively, interfering with cellular processes crucial for KRTAP20-3 function. Bay 11-7082 and PDTC act on NF-κB, disrupting downstream events associated with KRTAP20-3 signaling. SP010 selectively inhibits the Akt pathway, and NSC 23766 targets Rac1, both influencing pathways critical for KRTAP20-3 activation. This chemical class, through precise targeting of key cellular pathways, provides a robust toolkit for investigating and modulating KRTAP20-3 functionality at the molecular level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine, a potent protein kinase inhibitor, can block phosphorylation events involved in KRTAP20-3 activation, disrupting its functional pathways. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 inhibits p38 MAP kinase, which is associated with KRTAP20-3 signaling. Its action interferes with the downstream events linked to KRTAP20-3, suppressing its activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 targets PI3K, a signaling molecule upstream of KRTAP20-3. By inhibiting PI3K, it disrupts the activation of KRTAP20-3, leading to downstream pathway inhibition. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a MEK inhibitor, blocking the MAPK/ERK pathway, which is implicated in KRTAP20-3 activation. Its interference with this pathway inhibits KRTAP20-3 functionality. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a phosphoinositide 3-kinase (PI3K) inhibitor. By disrupting PI3K, it hinders the signaling cascade that contributes to the activation of KRTAP20-3. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a protein involved in the PI3K/Akt/mTOR pathway. This inhibition disrupts the pathway, thereby impacting the activation of KRTAP20-3. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits JNK, a kinase associated with various cellular processes. Inhibition of JNK disrupts signaling pathways related to KRTAP20-3, affecting its functionality. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059, a MEK inhibitor, disrupts the MAPK/ERK pathway implicated in KRTAP20-3 activation. Its interference with this pathway leads to inhibition of KRTAP20-3 functionality. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
Bay 11-7082 inhibits NF-κB activation, which is linked to KRTAP20-3 signaling. Its action disrupts the downstream events associated with KRTAP20-3, inhibiting its activity. | ||||||
KPT185 | 1333151-73-7 | sc-487916 | 10 mg | $220.00 | ||
SP010 is a selective inhibitor of the Akt pathway, affecting a key player in KRTAP20-3 activation. By inhibiting Akt, SP010 disrupts the signaling cascade, impacting KRTAP20-3. | ||||||