KRTAP19-2 Activators
KRTAP19-2, a member of the Keratin Associated Protein (KRTAP) family, plays a crucial role in the composition and structure of hair. These proteins intermingle with keratin fibers in hair cells, contributing to the diverse characteristics of hair such as its strength, resilience, and texture. KRTAPs are expressed within the specialized cells of the hair follicle during the hair growth cycle, particularly in the anagen phase, where active hair synthesis occurs. The expression of KRTAP19-2, like other hair-specific proteins, is a finely-tuned process, orchestrated by a symphony of molecular signals that ensure the structural integrity and proper function of hair. Understanding the regulation of such proteins is key to comprehending hair biology and the mechanisms underlying hair formation.
Various biochemical compounds have been identified as potential activators of KRTAP19-2 expression, each playing a conceivable role in the complex regulatory networks of hair follicle biology. For instance, retinoic acid, a derivative of vitamin A, is known for its role in cell differentiation and could conceivably upregulate KRTAP19-2 during the formation of the hair shaft. Similarly, biotin, often associated with hair and nail health, may promote the production of KRTAP19-2 by enhancing the metabolic processes in hair follicle cells. Trace elements like zinc and copper, integral components of numerous enzymes, are also thought to potentially stimulate the expression of hair structural proteins through their involvement in protein synthesis and cellular metabolism. Compounds such as minoxidil and caffeine, while typically discussed in the context of hair growth, may indirectly encourage the expression of KRTAP19-2 by extending the anagen phase, thus providing a conducive environment for the synthesis of keratin-associated proteins. It is through the intricate interplay of these activators that the expression of KRTAP19-2 is possibly modulated, contributing to the dynamic and robust nature of hair growth and maintenance.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid may upregulate KRTAP19-2 by signaling pathways that govern keratinocyte differentiation, prompting these cells to produce more hair-specific structural proteins. | ||||||
D-(+)-Biotin | 58-85-5 | sc-204706 sc-204706A sc-204706B | 1 g 5 g 25 g | $41.00 $107.00 $333.00 | 1 | |
Biotin could stimulate KRTAP19-2 expression by enhancing the metabolic processes that provide the necessary precursors for keratin-associated protein synthesis in hair follicles. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc sulfate may induce the transcriptional activity of genes encoding for hair matrix proteins, including KRTAP19-2, by stabilizing DNA-binding protein complexes. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
Copper(II) sulfate might stimulate the activity of enzymes that facilitate the expression of hair-specific proteins, potentially increasing the levels of KRTAP19-2 in hair follicle cells. | ||||||
Minoxidil (U-10858) | 38304-91-5 | sc-200984 sc-200984A | 100 mg 1 g | $69.00 $351.00 | ||
Minoxidil could induce KRTAP19-2 expression by prolonging the anagen phase of hair growth, which is associated with increased synthesis of keratin-associated proteins. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine may promote KRTAP19-2 expression by stimulating hair follicle cells to enter and prolong the anagen phase, where hair matrix protein synthesis is most active. | ||||||
Hydrocortisone | 50-23-7 | sc-300810 | 5 g | $102.00 | 6 | |
Elevated hydrocortisone can trigger a hormonal cascade that may upregulate KRTAP19-2 as part of the body's response to stress, potentially leading to changes in hair protein composition. | ||||||
L-Thyroxine, free acid | 51-48-9 | sc-207813 sc-207813A | 100 mg 500 mg | $35.00 $74.00 | 2 | |
L-Thyroxine could increase KRTAP19-2 expression by accelerating cellular metabolism in hair follicle cells, thereby boosting the production of structural proteins for hair. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate may induce KRTAP19-2 by activating signaling pathways that lead to the reinforcement of the hair's structural integrity, necessitating higher production of keratin-associated proteins. | ||||||
Selenium | 7782-49-2 | sc-250973 | 50 g | $62.00 | 1 | |
Selenium sulfide may increase the expression of KRTAP19-2 by contributing to the protective antioxidant environment necessary for optimal hair follicle function and protein synthesis. | ||||||